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The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles
Örebro University, School of Health and Medical Sciences. (RISPA)ORCID iD: 0000-0002-9831-0896
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2004 (English)In: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 558, no Pt 3, p. 1005-1012Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the modulation of satellite cell content and myonuclear number following 30 and 90 days of resistance training and 3, 10, 30, 60 and 90 days of detraining. Muscle biopsies were obtained from the vastus lateralis of 15 young men (mean age: 24 years; range: 20-32 years). Satellite cells and myonuclei were studied on muscle cross-sections stained with a monoclonal antibody against CD56 and counterstained with Mayer's haematoxylin. Cell cycle markers CyclinD1 and p21 mRNA levels were determined by Northern blotting. Satellite cell content increased by 19% (P= 0.02) at 30 days and by 31% (P= 0.0003) at 90 days of training. Compared to pre-training values, the number of satellite cells remained significantly elevated at 3, 10 and 60 days but not at 90 days of detraining. The two cell cycle markers CyclinD1 and p21 mRNA significantly increased at 30 days of training. At 90 days of training, p21 was still elevated whereas CyclinD1 returned to pre-training values. In the detraining period, p21 and CyclinD1 levels were similar to the pre-training values. There were no significant alterations in the number of myonuclei following the training and the detraining periods. The fibre area controlled by each myonucleus gradually increased throughout the training period and returned to pre-training values during detraining. In conclusion, these results demonstrate the high plasticity of satellite cells in response to training and detraining stimuli and clearly show that moderate changes in the size of skeletal muscle fibres can be achieved without the addition of new myonuclei.

Place, publisher, year, edition, pages
2004. Vol. 558, no Pt 3, p. 1005-1012
National Category
Medical and Health Sciences Physiology Social Sciences Interdisciplinary Sport and Fitness Sciences
Research subject
Sports Science
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URN: urn:nbn:se:oru:diva-6278DOI: 10.1113/jphysiol.2004.065904PubMedID: 15218062OAI: oai:DiVA.org:oru-6278DiVA, id: diva2:211704
Available from: 2009-04-17 Created: 2009-04-17 Last updated: 2018-01-13Bibliographically approved

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Kadi, Fawzi

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