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Differential NF-κB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance
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2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 7, 2371-2376 p.Article in journal (Refereed) Published
Abstract [en]

How do we acquire immune tolerance against food microorganisms and commensal bacteria that constitute the intestinal microbiota? We investigated this by stimulating the immune system of adults with commensal Lactobacillus plantarum bacteria. We studied the in vivo human responses to L. plantarum in a randomized double-blind placebo-controlled cross-over study. Healthy adults ingested preparations of living and heat-killed L. plantarum bacteria. Biopsies were taken from the intestinal duodenal mucosa and altered expression profiles were analyzed using whole-genome microarrays and by biological pathway reconstructions. Expression profiles of human mucosa displayed striking differences in modulation of NF-kappaB-dependent pathways, notably after consumption of living L. plantarum bacteria in different growth phases. Our in vivo study identified mucosal gene expression patterns and cellular pathways that correlated with the establishment of immune tolerance in healthy adults.

Place, publisher, year, edition, pages
Washington, DC: National Academy of Sciences , 2009. Vol. 106, no 7, 2371-2376 p.
National Category
Medical and Health Sciences Clinical Medicine Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-6681DOI: 10.1073/pnas.0809919106PubMedID: 19190178OAI: oai:DiVA.org:oru-6681DiVA: diva2:216448
Available from: 2009-05-08 Created: 2009-05-08 Last updated: 2015-03-02Bibliographically approved

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