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SPE and HPLC/UV of resin acids in colophonium-containing products
Örebro University, School of Health and Medical Sciences.
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2008 (English)In: Journal of Separation Science, ISSN 1615-9306, E-ISSN 1615-9314, Vol. 31, no 15, 2784-2790 p.Article in journal (Refereed) Published
Abstract [en]

A new method, involving SPE and HPLC/UV diode-array detection (DAD), was developed for the quantification of colophonium components in different consumer products, such as cosmetics. Colophonium is a common cause of contact dermatitis since its components can oxidize into allergens on exposure to air. Three different resin acids were used as markers for native and oxidized colophonium, abietic acid (AbA), dehydroabietic acid (DeA), and 7-oxodehydroabietic acid (7-O-DeA). The SPE method, utilizing a mixed-mode hydrophobic and anion exchange retention mechanism, was shown to yield very clean extracts. The use of a urea-embedded C(12) HPLC stationary phase improved the separation of the resin acids compared to common C(18). Concentrations higher than 2 mg/g of both AbA and DeA were detected in wax strips. In this product also 7-O-DeA, a marker for oxidized colophonium, was detected at a level of 28 microg/g. The LODs were in the range of 7-19 microg/g and the LOQs 22-56 microg/g. The method is simple to use and can be applied on many types of technical products, not only cosmetics. For the first time, a method for technical products was developed, which separates AbA from pimaric acid.

Place, publisher, year, edition, pages
Weinheim, Fed. Rep. of Germany: Wiley-VCH , 2008. Vol. 31, no 15, 2784-2790 p.
National Category
Medical and Health Sciences Environmental Health and Occupational Health
Research subject
Occupational and Environmental Medicine
Identifiers
URN: urn:nbn:se:oru:diva-6959DOI: 10.1002/jssc.200800210PubMedID: 18666177OAI: oai:DiVA.org:oru-6959DiVA: diva2:219471
Available from: 2009-05-27 Created: 2009-05-27 Last updated: 2010-09-22Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
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Output format
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  • asciidoc
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