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The role of SPINK1 in ETS rearrangement-negative prostate cancers
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2008 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 13, no 6, 519-28 p.Article in journal (Refereed) Published
Abstract [en]

ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2008. Vol. 13, no 6, 519-28 p.
National Category
Medical and Health Sciences Cancer and Oncology Urology and Nephrology Cell and Molecular Biology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-7063DOI: 10.1016/j.ccr.2008.04.016PubMedID: 18538735OAI: oai:DiVA.org:oru-7063DiVA: diva2:220851
Available from: 2009-06-02 Created: 2009-06-02 Last updated: 2016-08-10Bibliographically approved

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Andrén, OveFall, Katja
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