oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of SPINK1 in ETS rearrangement-negative prostate cancers
Show others and affiliations
2008 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 13, no 6, p. 519-28Article in journal (Refereed) Published
Abstract [en]

ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2008. Vol. 13, no 6, p. 519-28
National Category
Medical and Health Sciences Cancer and Oncology Urology and Nephrology Cell and Molecular Biology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-7063DOI: 10.1016/j.ccr.2008.04.016PubMedID: 18538735OAI: oai:DiVA.org:oru-7063DiVA, id: diva2:220851
Available from: 2009-06-02 Created: 2009-06-02 Last updated: 2018-01-13Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Andrén, OveFall, Katja

Search in DiVA

By author/editor
Andrén, OveFall, Katja
By organisation
School of Health and Medical Sciences
In the same journal
Cancer Cell
Medical and Health SciencesCancer and OncologyUrology and NephrologyCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 301 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf