oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer
Linköpings Universitet.
Örebro University, School of Health and Medical Sciences.
Örebro University, School of Health and Medical Sciences.
2009 (English)In: Oncology Reports, ISSN 1021-335X, E-ISSN 1791-2431, Vol. 22, no 3, 575-579 p.Article in journal (Refereed) Published
Abstract [en]

The p53 protein and its regulator MDM2 is central to tumorigenesis by directing cells to undergo cell cycle arrest and/or apoptosis in response to DNA damage or other stress signals. The genes encoding these proteins contain nucleotide variation (p53 codon 72, MDM2 SNP309) that influences cellular response. We examined the p53 codon 72 and MDM2 SNP309 to determine their implication with age of disease onset and risk of breast cancer in young women (≤36 years). No risk of breast cancer was observed for the genotypes of p53 and MDM2, however, a tendency (P=0.15) towards increased risk of early onset breast cancer was observed in carriers of two or more Pro and/or G alleles. We further calculated the influence on age at diagnosis. Cases were grouped according to the number of G and Pro alleles (0, 1, 2 or 3-4) and age at diagnosis. A significant trend towards decreased age at diagnosis with increased number of risk alleles was found (P=0.013). Our results suggest that p53 codon 72 and MDM2 SNP309 may be implicated in early onset breast cancer.

Place, publisher, year, edition, pages
Athens, Greece: Spandidos Publications , 2009. Vol. 22, no 3, 575-579 p.
National Category
Cell and Molecular Biology
Research subject
Genetics
Identifiers
URN: urn:nbn:se:oru:diva-8592DOI: 10.3892/or_00000474ISI: 000268734600020PubMedID: 19639206Scopus ID: 2-s2.0-70349316753OAI: oai:DiVA.org:oru-8592DiVA: diva2:277338
Available from: 2009-11-17 Created: 2009-11-17 Last updated: 2017-02-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Palmebäck Wegman, PiaWingren, Sten
By organisation
School of Health and Medical Sciences
In the same journal
Oncology Reports
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf