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Evidence of High dot OH Radical Quenching Efficiency by Vitamin B-6
Euskal Herriko Unibertsitatea.
Euskal Herriko Unibertsitatea.
Örebro University, School of Science and Technology. (Molekylär biokemi)
Örebro University, School of Science and Technology. (Molekylär biokemi)ORCID iD: 0000-0003-3315-8835
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2009 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 113, no 29, 9629-9632 p.Article in journal (Refereed) Published
Abstract [en]

Molecules acting as antioxidants capable of scavenging reactive oxygen species (ROS) are of the utmost importance in the living cell. The antioxidative properties of pyridoxine (vitamin B6) have recently been discovered. Previous theoretical calculations have shown a high reactivity of pyridoxine toward hydroxyl radicals, where the latter preferably abstract H from either carbon of the two methanol substituents (C8 or C9). In this study, we have explored the reactivity of pyridoxine toward further hydroxyl radicals, considering as the first step the H abstraction from either C8 or C9, also including addition reactions and cyclization. Many of the reactions display similar ΔG, and hence, the quenching of hydroxyl radicals by pyridoxine may undergo different pathways leading to a mix of products. In addition, we observe that pyridoxine, under high hydroxyl radical concentrations, may scavenge up to eight radicals, supporting its observed high antioxidant activity.

Place, publisher, year, edition, pages
Washington, D. C.: American Chemical Society (ACS), 2009. Vol. 113, no 29, 9629-9632 p.
National Category
Biochemistry and Molecular Biology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-8660DOI: 10.1021/jp903023cISI: 000268139600001PubMedID: 19558175Scopus ID: 2-s2.0-67650803228OAI: oai:DiVA.org:oru-8660DiVA: diva2:278695
Available from: 2009-11-28 Created: 2009-11-28 Last updated: 2017-02-23Bibliographically approved

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