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Interaction of metallothionein with tumor suppressor p53 protein
Örebro University, Department of Natural Sciences.ORCID iD: 0000-0001-7336-6335
2006 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 580, no 5, 1235-1238 p.Article in journal (Refereed) Published
Abstract [en]

Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro. The complex between MT and p53 was observed in breast cancer epithelial cells with both wild and inactive type of p53. Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT. Our data suggest that co-expression of MT and p53 and their complex formation in tumor cells may be involved in regulation of apoptosis in these cells.

Place, publisher, year, edition, pages
2006. Vol. 580, no 5, 1235-1238 p.
National Category
Biological Sciences
Research subject
Biology
Identifiers
URN: urn:nbn:se:oru:diva-8833DOI: 10.1016/j.febslet.2006.01.036PubMedID: 16442532OAI: oai:DiVA.org:oru-8833DiVA: diva2:281951
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2016-12-13Bibliographically approved

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