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Regulation of Arctic char (Salvelinus alpinus) egg shell proteins and vitellogenin during reproduction and in response to 17beta-estradiol and cortisol
Örebro University, School of Science and Technology.ORCID iD: 0000-0002-4954-926X
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-7336-6335
2004 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 135, no 3, 276-285 p.Article in journal (Refereed) Published
Abstract [en]

Estrogens induce both vitellogenin (Vtg) and egg shell (zona pellucida; ZP) protein synthesis in salmonids. However, while Vtg is strictly under estrogenic control, recent reports suggest that additional mechanisms are involved in ZP protein synthesis. During sexual maturation both estrogen and glucocorticoid levels increase in the circulation of female fish. As glucocorticoids have been shown to interfere with Vtg induction in fish we investigated whether cortisol (F) had similar effects on ZP regulation. In the present study we determined both the natural variation in Vtg and ZP during an annual reproductive cycle in female Arctic char (Salvelinus alpinus), and the effect of co-treatment of juvenile Arctic char with 17beta-estradiol (E2) and F. During sexual maturation the expression of Vtg and ZP correlated to plasma levels of E2 and F. Determination of Vtg and ZP protein levels following co-treatment with E2 and F showed that F antagonized E2 induction of Vtg. However, F was observed to potentiate the expression of ZP protein in the same fish. These results indicate that in Arctic char Vtg and ZP proteins are not regulated by the same mechanisms and suggest that ZP protein expression does not necessarily imply exposure to estrogenic compounds alone, and may thus not be ideally suited as a biomarker of exposure to estrogenic compounds.

Place, publisher, year, edition, pages
2004. Vol. 135, no 3, 276-285 p.
National Category
Biological Sciences
Research subject
Biology
Identifiers
URN: urn:nbn:se:oru:diva-8842DOI: 10.1016/j.ygcen.2003.10.004PubMedID: 14723879OAI: oai:DiVA.org:oru-8842DiVA: diva2:281961
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2016-12-13Bibliographically approved

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Berg, A. H.Olsson, Per-Erik
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CiteExportLink to record
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Citation style
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