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Mortality trends in subjects with and without diabetes during 33 years of follow up
Örebro University, Department of Clinical Medicine. Uppsala Univ, Dept Publ Hlth & Caring Sci, Family Med & Clin Epidemiol Sect, Uppsala, Sweden. (AFC)ORCID iD: 0000-0001-6864-4679
Uppsala Univ, Dept Publ Hlth & Caring Sci, Family Med & Clin Epidemiol Sect, Uppsala, Sweden; Natl Board Hlth & Welf, Div Reg Supervis Author, Orebro, Sweden.
Uppsala Univ, Dept Publ Hlth & Caring Sci, Family Med & Clin Epidemiol Sect, Uppsala, Sweden.
2009 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 33, no 3, 551-556 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Mortality rates have declined substantially over the past decades in the general population, but the situation among diabetic subjects is less clear. The aim of this study was to analyze mortality trends in diabetic and nondiabetic subjects during 1972–2004.

Research design and methods: Since 1972, all patients with diabetes are entered in a diabetes register at Laxå Primary Health Care Center; 776 incident cases were recorded up to 2001. The register has been supplemented with a nondiabetic population of 3,880 subjects and with data from the National Cause of Death Register during 1972 to 2004.

Results: During the 33-year follow-up period, 233 (62.0%) diabetic women and 240 (60.0%) diabetic men and 995 (52.9%) nondiabetic women and 1,082 (54.1%) nondiabetic men died. The age-adjusted hazard ratio (HR) for all-cause mortality among diabetic and nondiabetic subjects was 1.17 (P < 0.0021) for all, 1.22 (P < 0.007) for women, and 1.13 (P = 0.095) for men. The corresponding cardiovascular disease (CVD) mortality HRs were 1.33 (P < 0.0001), 1.41 (P < 0.0003), and 1.27 (P < 0.0093), respectively. The CVD mortality reduction across time was significant in nondiabetic subjects (P < 0.0001) and in men with diabetes (P = 0.014) but not in diabetic women (P = 0.69). The results regarding coronary heart disease (CHD) were similar (P < 0.0001, P < 0.006, and P = 0.17, respectively). The CVD and CHD mortality rate change across time was fairly linear in all groups.

Conclusions: Diabetic subjects had less mortality rate reduction during follow-up than nondiabetic subjects. However the excess mortality risk for diabetic subjects was smaller than that found in other studies.

Place, publisher, year, edition, pages
Alexandria, USA: American Diabetes Association , 2009. Vol. 33, no 3, 551-556 p.
National Category
Medical and Health Sciences Clinical Medicine Endocrinology and Diabetes
Research subject
Medicine; English; English
Identifiers
URN: urn:nbn:se:oru:diva-9717DOI: 10.2337/dc09-0680ISI: 000275562700019PubMedID: 20009100Scopus ID: 2-s2.0-77649256893OAI: oai:DiVA.org:oru-9717DiVA: diva2:293577
Available from: 2010-02-12 Created: 2010-02-12 Last updated: 2017-02-14Bibliographically approved

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