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Aberrant amino acid transport in fibroblasts from children with autism
(Assoc. Prof. Nikolaos Venizelos)
Örebro University, Department of Clinical Medicine. (Prof. Nikolaos Venizelos)
(Prof. Nikolaos Venizelos)
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2007 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 418, no 1, 82-86 p.Article in journal (Refereed) Published
Abstract [en]

Autism is a developmental, cognitive disorder clinically characterized by impaired social interaction, communication and restricted behaviours. The present study was designed to explore whether an abnormality in transport of tyrosine and/or alanine is present in children with autism. Skin biopsies were obtained from 11 children with autism (9 boys and 2 girls) fulfilling the DSM-IV diagnostic criteria for autistic disorder and 11 healthy male control children. Transport of amino acids tyrosine and alanine across the cell membrane of cultured fibroblasts was studied by the cluster tray method. The maximal transport capacity, Vmax and the affinity constant of the amino acid binding sites, Km, were determined. Significantly increased Vmax for alanine (p = 0.014) and increased Km for tyrosine (p = 0.007) were found in children with autism. The increased transport capacity of alanine across the cell membrane and decreased affinity for transport sites of tyrosine indicates the involvement of two major amino acid transport systems (L- and A-system) in children with autism. This may influence the transport of several other amino acids across the blood–brain-barrier. The significance of the findings has to be further explored. © 2007 Elsevier Ireland Ltd. All rights reserved

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2007. Vol. 418, no 1, 82-86 p.
Keyword [en]
Autism; Amino acid transport; Fibroblasts; Tyrosine; Alanine
National Category
Psychiatry Neurosciences
Research subject
Child and Youth Psychiatry; Medicine
Identifiers
URN: urn:nbn:se:oru:diva-9861DOI: 10.1016/j.neulet.2007.03.004OAI: oai:DiVA.org:oru-9861DiVA: diva2:300939
Available from: 2010-03-01 Created: 2010-03-01 Last updated: 2016-12-12Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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