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Vestibular and audiologic functions in gentamicin-treated Menière's disease
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6557-6359
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1988 (English)In: American Journal of Otolaryngology, ISSN 0196-0709, E-ISSN 1532-818X, Vol. 9, no 5, 383-391 p.Article in journal (Refereed) Published
Abstract [en]

Fifteen patients with disabling Meniere's disease were treated with local intratympanic administration of gentamicin once daily. They had suffered from frequent attacks of vertigo and vomiting, the hearing in the affected ears was decreased permanently, and spontaneous nystagmus was observed. The number of treatment days ranged between 3 and 11. Follow-up time was 1 to 6 years. For evaluation of the treatment, audiologic and vestibular examinations were used, including the broad frequency-band rotatory test (0.4-4.5 Hz). Fourteen patients were free from vertigo after treatment. In 5 patients, there was an increased hearing loss, and in 10 it remained unchanged. Tinnitus and fullness sensations were diminished. After treatment, all ears were unresponsive to caloric stimulation. The clinical examination and rotatory testing in light with sinusoidal stimulation revealed good central compensation of the vestibular loss. However, with pseudorandomized oscillations in darkness, the broad frequency-band rotatory test quantified the loss of peripheral vestibular function and was able to detect the side of the lesion in eight of nine patients.

Place, publisher, year, edition, pages
1988. Vol. 9, no 5, 383-391 p.
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-9889OAI: oai:DiVA.org:oru-9889DiVA: diva2:301455
Available from: 2010-03-03 Created: 2010-03-03 Last updated: 2016-12-16Bibliographically approved

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