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Effects of loratadine on postural control
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6557-6359
1994 (English)In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, Vol. 520, no Pt 2, 310-312 p.Article in journal (Refereed) Published
Abstract [en]

The effects of classical sedating antihistamines on cognitive and perceptual functions are well known. Loratadine is a new antihistamine without sedative effects. In this study, loratadine 10 and 40 mg daily, clemastine 2 mg twice daily and placebo were evaluated in 8 healthy subjects in terms of effects on equilibrium as measured with dynamic posturography. Dynamic posturography comprises a sensory organization part in which the support surface and visual surround are either stable or referenced to the patient's sway, with eyes open or closed. In a movement coordination part, the platform makes active movements. Analysis of variance showed no effects on equilibrium attributable to loratadine. Comparing substances pairwise, however, a significant difference between loratadine and clemastine was displayed in 2 out of 6 sensory test conditions. In conclusion, loratadine can be considered safe regarding balance functions.

Place, publisher, year, edition, pages
1994. Vol. 520, no Pt 2, 310-312 p.
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-10055OAI: oai:DiVA.org:oru-10055DiVA: diva2:304297
Available from: 2010-03-17 Created: 2010-03-17 Last updated: 2016-12-16Bibliographically approved

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