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BCRP mRNA expression v. clinical outcome in 40 adult AML patients
Department of Medicine, Örebro University Hospital, Örebro; Karolinska Institute, Stockholm.
Clinical Research Centre, Örebro University Hospital, Örebro.
Örebro University, Department of Nursing and Caring Sciences.
Department of Haematology, Huddinge University Hospital, Stockholm; Karolinska Institute, Stockholm.
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2005 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 29, no 2, 141-146 p.Article in journal (Refereed) Published
Abstract [en]

Efflux pumps are considered being mechanisms behind drug resistance in acute myeloid leukaemia (AML). A recently described efflux pump, breast cancer resistance protein (BCRP), can be expressed in AML, but its clinical importance is uncertain. In this study BCRP mRNA expression was determined in samples from 40 AML patients by real-time RT-PCR. The expression varied from negative to 76 times that of control cells. There was no difference in BCRP mRNA expression between patients responding to induction treatment and non-responders. However, in the group of responders, the 14 patients with the highest expression had significantly shorter overall survival (mean 38 months, SEM 15 months) than the 14 patients with the lowest (74 months, SEM 16 months) (P = 0.047). This suggests a possible role of BCRP in drug resistance in AML.

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2005. Vol. 29, no 2, 141-146 p.
Keyword [en]
Breast cancer resistance protein, acute myeloid leukaemia, drug resistance, prognosis, reverse transcriptase polymerase chain reaction
National Category
Medical and Health Sciences
Research subject
Medicine; Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-10518DOI: 10.1016/j.leukres.2004.06.004ISI: 000226269500006PubMedID: 15607361Scopus ID: 2-s2.0-10644230985OAI: oai:DiVA.org:oru-10518DiVA: diva2:313644
Available from: 2010-04-27 Created: 2010-04-27 Last updated: 2016-08-10Bibliographically approved
In thesis
1. Biological markers in breast cancer and acute leukaemia with focus on drug resistance
Open this publication in new window or tab >>Biological markers in breast cancer and acute leukaemia with focus on drug resistance
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2010. 68 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 43
Keyword
Breast cancer, acute leukaemia, drug resistance, toposiomerase IIa, BCRP, HER2, SLC25A43, flow cytometry, real time PCR, whole genome screening
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Biomedicine
Identifiers
urn:nbn:se:oru:diva-10519 (URN)978-91-7668-724-6 (ISBN)
Public defence
2010-05-21, Bohmanssonsalen, Universitetssjukhuset, Örebro, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2010-04-27 Created: 2010-04-27 Last updated: 2011-04-26Bibliographically approved

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Uggla, BertilWågsäter, DickKarlsson, Mats G.Sirsjö, AllanTidefelt, Ulf
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CiteExportLink to record
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