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A common variant associated with prostate cancer in European and African populations
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2006 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 38, no 6, 652-658 p.Article in journal (Refereed) Published
Abstract [en]

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

Place, publisher, year, edition, pages
2006. Vol. 38, no 6, 652-658 p.
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Medical and Health Sciences Cancer and Oncology
Research subject
Oncology
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URN: urn:nbn:se:oru:diva-11091DOI: 10.1038/ng1808PubMedID: 16682969OAI: oai:DiVA.org:oru-11091DiVA: diva2:324902
Available from: 2010-06-16 Created: 2010-06-16 Last updated: 2017-12-12Bibliographically approved

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Johansson, Jan-Erik

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