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Fc gamma RIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD)
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
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2007 (English)In: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, E-ISSN 1476-1645, Vol. 77, no 6, 1074-8 p.Article in journal (Refereed) Published
Abstract [en]

The pathologic manifestations of Onchocerca volvulus infection depend on the interplay between the host and the parasite. A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. This study investigated the relationship between this polymorphism and disease outcome. Fc gamma RIIa genotyping was performed on clinically characterized onchocerciasis patients (N = 100) and healthy controls (N = 74). Fc gamma RIIa genotype R/R131 frequencies were significantly higher among patients with severe dermatopathology (P < 0.001). Increased risk of developing this form was mostly associated with one tribe (Masalit) (OR = 3.2, 95% CI 1-9.9, P = 0.042). The H131 allele was found to be significantly associated with a reduced risk of having the severe form of the disease (adjusted OR = 0.26, 95% CI = 0.13-0.46, P < 0.001). Our findings suggest that the polymorphism influences the clinical outcome of onchocerciasis.

Place, publisher, year, edition, pages
Lawrence, Kans.: American society of tropical medicine and hygiene , 2007. Vol. 77, no 6, 1074-8 p.
National Category
Medical and Health Sciences Medical Genetics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-11541PubMedID: 18165525OAI: oai:DiVA.org:oru-11541DiVA: diva2:342902
Available from: 2010-08-11 Created: 2010-08-11 Last updated: 2017-12-12Bibliographically approved

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PubMedhttp://www.ajtmh.org/cgi/content/full/77/6/1074

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Montgomery, Scott M.

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CiteExportLink to record
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