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Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania
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2007 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 195, no 4, 597-601 p.Article in journal (Refereed) Published
Abstract [en]

We assessed the influence that consecutive-day blood sampling, compared with single-day blood sampling, had on polymerase chain reaction (PCR)-adjusted parasitological cure after stepwise genotyping of merozoite surface proteins 2 (msp2) and 1 (msp1) in 106 children in Tanzania who had uncomplicated falciparum malaria treated with either sulfadoxine-pyrimethamine or artemether-lumefantrine; 78 of these children developed recurrent parasitemia during the 42-day follow-up period. Initial msp2 genotyping identified 27 and 33 recrudescences by use of single- and consecutive-day sampling, respectively; in subsequent msp1 genotyping, 17 and 21 of these episodes, respectively, were still classified as recrudescences; these results indicate a similar sensitivity of the standard single-day PCR protocol--that is, 82% (27/33) and 81% (17/21), in both genotyping steps. Interpretation of PCR-adjusted results will significantly depend on methodology.

Place, publisher, year, edition, pages
Chicago: University of Chicago Press , 2007. Vol. 195, no 4, 597-601 p.
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Medical and Health Sciences Infectious Medicine
Research subject
Infectious Diseases
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URN: urn:nbn:se:oru:diva-11573DOI: 10.1086/510910PubMedID: 17230421OAI: oai:DiVA.org:oru-11573DiVA: diva2:343504
Available from: 2010-08-13 Created: 2010-08-13 Last updated: 2017-12-12Bibliographically approved

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Montgomery, Scott M.

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