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Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile
Örebro University, School of Health and Medical Sciences.
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2007 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 51, no 5, p. 1840-1843Article in journal (Refereed) Published
Abstract [en]

In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.

Place, publisher, year, edition, pages
Washington, DC: American Society for Microbiology , 2007. Vol. 51, no 5, p. 1840-1843
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Medical and Health Sciences Microbiology in the medical area
Research subject
Medicine
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URN: urn:nbn:se:oru:diva-11576DOI: 10.1128/AAC.01283-06PubMedID: 17307985OAI: oai:DiVA.org:oru-11576DiVA: diva2:343510
Available from: 2010-08-13 Created: 2010-08-13 Last updated: 2018-01-12Bibliographically approved

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Norén, Torbjörn

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