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Atorvastatin and persistent atrial fibrillation following cardioversion: a randomized placebo-controlled multicentre study
Örebro University, School of Health and Medical Sciences.
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2009 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 30, no 7, p. 827-833Article in journal (Refereed) Published
Abstract [en]

AIMS: To evaluate the effect of atorvastatin in achieving stable sinus rhythm (SR) 30 days after electrical cardioversion (CV) in patients with persistent atrial fibrillation (AF). METHODS AND RESULTS: The study included 234 patients. The patients were randomized to treatment with atorvastatin 80 mg daily (n = 118) or placebo (n = 116) in a prospective, double-blinded fashion. Treatment was initiated 14 days before CV and was continued 30 days after CV. The two groups were well-balanced with respect to baseline characteristics. Mean age was 65 +/- 10 years, 76% of the patients were male and 4% had ischaemic heart disease. Study medication was well-tolerated in all patients but one. Before primary endpoint 12 patients were excluded. In the atorvastatin group 99 patients (89%) converted to SR at electrical CV compared with 95 (86%) in the placebo group (P = 0.42). An intention-to-treat analysis with the available data, by randomization group, showed that 57 (51%) in the atorvastatin group and 47 (42%) in the placebo group were in SR 30 days after CV (OR 1.44, 95%CI 0.85-2.44, P = 0.18). CONCLUSION: Atorvastatin was not statistically superior to placebo with regards to maintaining SR 30 days after CV in patients with persistent AF.

Place, publisher, year, edition, pages
Philadelphia: W.B. Saunders , 2009. Vol. 30, no 7, p. 827-833
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
URN: urn:nbn:se:oru:diva-11644DOI: 10.1093/eurheartj/ehp006PubMedID: 19202157OAI: oai:DiVA.org:oru-11644DiVA: diva2:345858
Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Atrial fibrillation: inflammatory and pharmacological studies
Open this publication in new window or tab >>Atrial fibrillation: inflammatory and pharmacological studies
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2012. p. 75
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 70
Keyword
Atrial fibrillation, inflammation, randomised, sudden cardiac
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-22590 (URN)978-91-7668-875-5 (ISBN)
Public defence
2012-06-15, Wilandersalen, Universitetssjukhuset, Örebro, 09:00 (Swedish)
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Available from: 2012-04-19 Created: 2012-04-19 Last updated: 2017-10-17Bibliographically approved

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Almroth, HenrikEnglund, Anders

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