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Lactase Persistence and Lactase Non-Persistence: Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
Örebro University, School of Health and Medical Sciences.
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet , 2010. , 45 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 48
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-11854ISBN: 978-91-7668-767-3 (print)OAI: oai:DiVA.org:oru-11854DiVA: diva2:352032
Public defence
2010-12-15, Wilandersalen, Universitetssjukhuset Örebro, Fakultetsgatan 1, 701 82 Örebro, 09:00
Opponent
Supervisors
Available from: 2010-09-17 Created: 2010-09-17 Last updated: 2011-04-21Bibliographically approved
List of papers
1. Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
Open this publication in new window or tab >>Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
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2007 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 42, no 2, 165-170 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Adult-type hypolactasia (AtH) can be diagnosed by genotyping in addition to functional tests or intestinal biopsy. The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century. MATERIAL AND METHODS: Schoolchildren (n=690) born in 1983 and 1989, and elderly individuals (n=392) born between 1920 and 1932 were genotyped for AtH using Pyrosequencing technology. RESULTS: The overall prevalence of AtH among children was 14.1%. The majority of children (92%, n=635) were Caucasians with genotype prevalences: CC, 61 (10%); CT, 259 (41%); TT, 307 (49%). The frequency of the mutated allele q was 0.300 in this cohort. The prevalence of AtH estimated from the Hardy-Weinberg equilibrium (HWE) (q 2), was 9.0% (95% CI: 6.7-11.2%). Eight percent (n=55) of the children were non-Caucasian; genotype prevalences were CC, 36 (66%); CT, 15 (27%); TT, 4 (7%). The prevalence of AtH in these children estimated from HWE was 62.5% (95% CI: 49.7-75.3%). The elderly subjects were all Caucasians. Their genotype prevalences were: CC, 20 (5%); CT, 166 (42%); TT, 206 (53%); the frequency of the mutated allele q was 0.262 and their AtH prevalence estimated from HWE was 6.8% (95% CI: 4.3-9.2%). CONCLUSIONS: The overall prevalence of AtH in children (14%) was higher than previously thought. Among Caucasians, higher figures were seen in children than in the elderly (9% versus 6.8%). The prevalence thus seems to be increasing and this may be due to the immigration of both non-Caucasian and Caucasian groups with a higher prevalence of AtH.

Place, publisher, year, edition, pages
Oslo: Taylor & Francis, 2007
National Category
Medical and Health Sciences Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-11542 (URN)10.1080/00365520600825257 (DOI)17327935 (PubMedID)
Available from: 2010-08-11 Created: 2010-08-11 Last updated: 2016-12-02Bibliographically approved
2. Body fat and dairy product intake in lactase persistent and non-persistent children and adolescents
Open this publication in new window or tab >>Body fat and dairy product intake in lactase persistent and non-persistent children and adolescents
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2010 (English)In: Food & Nutrition Research, ISSN 1654-6628, E-ISSN 1654-661X, Vol. 54, 5141Article in journal (Refereed) Published
Abstract [en]

Background: Lactase non-persistent (LNP) individuals may be lactose intolerant and therefore on a more restricted diet concerning milk and milk products compared to lactase persistent (LP) individuals. This may have an impact on body fat mass.

Objective This study examines if LP and LNP children and adolescents, defined by genotyping for the LCT-13910 C > T polymorphism, differ from each other with regard to milk and milk product intake, and measures of body fat mass.

Design: Children (n=298, mean age 9.6 years) and adolescents (n=386, mean age 15.6 years), belonging to the Swedish part of the European Youth Heart Study, were genotyped for the LCT-13910 C > T polymorphism. Dietary intakes of reduced and full-fat dairy varieties were determined.

Results: LNP (CC genotype) subjects consumed less milk, soured milk and yoghurt compared to LP (CT/TT genotype) subjects (p<0.001). Subsequent partitioning for age group attenuated this observation (p=0.002 for children and p=0.023 in adolescents). Six subjects were reported by parents to be 'lactose intolerant', none of whom were LNP. LNP children and adolescents consumed significantly less reduced fat milk and milk products than LP children and adolescents (p=0.009 for children and p=0.001 for adolescents).

Conclusions: We conclude that LP is linked to an overall higher milk and dairy intake, but is not linked to higher body fat mass in children and adolescents.

Place, publisher, year, edition, pages
Järfälla, Sweden: Co-action Publishing, 2010
National Category
Medical and Health Sciences Nutrition and Dietetics
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-15350 (URN)10.3402/fnr.v54i0.5141 (DOI)000208683500006 ()20585563 (PubMedID)2-s2.0-77955476574 (Scopus ID)
Available from: 2011-04-21 Created: 2011-04-21 Last updated: 2017-02-15Bibliographically approved
3. Milk consumption and body height in preadolescent and adolescent children
Open this publication in new window or tab >>Milk consumption and body height in preadolescent and adolescent children
(English)Manuscript (preprint) (Other academic)
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-15352 (URN)
Available from: 2011-04-21 Created: 2011-04-21 Last updated: 2016-12-02Bibliographically approved
4. Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
Open this publication in new window or tab >>Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
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2009 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 49, no 3, 141-146 p.Article in journal (Refereed) Published
Abstract [en]

Background: The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS).

AIim of the study: The aim was to determine if milk intake and MS are associated. We applied Mendelian randomization (MR). The SNP, LCT -13910 C>T, with the genotypes LP (TT/CT) and LNP (CC), was taken as a proxy for milk consumption.

Methods: A representative sample of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain aged 18-75 years (n = 551) was genotyped for the LCT -13910 C>T polymorphism. We used the International Diabetes Federation (IDF) criteria to define MS. RESULTS: 60% of the population was LP and 40% LNP. One hundred seven LP subjects (35.0%) and 53 LNP subjects (25.6%) showed MS (chi (2) = 5.04, p = 0.025). LP subjects showed a significantly higher odds ratio (OR) for MS than LNP subjects computed for the whole population: both the crude OR (1.56; 95% CI 1.06-2.31) and adjusted OR for sex, age, daily energy intake, physical activity and educational level (1.57; 95% CI 1.02-2.43). Adjusted OR for women with LP was 1.93; 95% CI 1.06-3.52.

Conclusions: The T allele of the SNP might constitute a nutrigenetic factor increasing the susceptibility of LP subjects, especially women, to develop MS in the Canary Islands.

Place, publisher, year, edition, pages
Heidelberg, Germany: Springer, 2009
Keyword
LCT-13910 C > T polymorphism, Metabolic syndrome, Metabolic syndrome, Milk, Mendelian randomization
National Category
Medical and Health Sciences Physiology Nutrition and Dietetics
Research subject
Nutrition
Identifiers
urn:nbn:se:oru:diva-9716 (URN)10.1007/s00394-009-0058-2 (DOI)000275631500002 ()19844753 (PubMedID)2-s2.0-77950864600 (Scopus ID)
Available from: 2010-02-12 Created: 2010-02-12 Last updated: 2017-02-14Bibliographically approved

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