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Seroprevalence of antibodies against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis
Örebro University, School of Health and Medical Sciences.
Örebro University, Örebro, Sweden.
2009 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 27, no 42, p. 5755-5759Article in journal (Refereed) Published
Abstract [en]

The IgG antibody levels directed against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis, were examined in order to investigate the extent of natural immunisation against these antigens in different age groups. As a comparison, the IgG antibody levels against Haemophilus influenzae type b were examined. In the two youngest age groups, below 10 years of age, relatively low levels of both anti-fHbp and anti-NadA were measured. A 15-fold higher geometric mean concentration of anti-fHbp was noted in the age group 20-29 years as compared to the age group 15-19 years. The peak concentration was found at 30-39 years, followed by decreased levels with age. Anti-NadA showed a certain increase up to 9 years followed by an even increase up to 40-49 years.

Place, publisher, year, edition, pages
2009. Vol. 27, no 42, p. 5755-5759
National Category
Medical and Health Sciences Microbiology in the medical area
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-11988DOI: 10.1016/j.vaccine.2009.07.056PubMedID: 19654065OAI: oai:DiVA.org:oru-11988DiVA, id: diva2:354639
Available from: 2010-10-04 Created: 2010-10-04 Last updated: 2018-04-16Bibliographically approved

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Jacobsson, Susanne

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