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Association of common variants of UCP2 gene with low-grade inflammation in Swedish children and adolescents: the European Youth Heart Study
Örebro University, School of Health and Medical Sciences.
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2009 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 66, no 3, 350-354 p.Article in journal (Refereed) Published
Abstract [en]

We examined the associations of two functional variants 866G>A and DEL/INS polymorphisms of UCP2 gene with low-grade inflammatory proteins (C-reactive protein, fibrinogen, complement C3 [C3], and complement C4 [C4]) in 131 children (52.7% boys, aged 9.5 +/- 0.4 y) and 118 adolescents (44.1% males, aged 15.5 +/- 0.4 y) selected from the European Youth Heart Study. Differences in inflammatory markers among the genotype variants of the two UCP2 gene polymorphisms were analyzed after adjusting for sex, age, pubertal stage, fitness, and fatness. The results showed that fibrinogen, C3, and C4 were higher in GG carriers than in subjects carrying the A allele of the 866G>A polymorphism of the UCP2 gene (UCP2 -866G>A) polymorphism (all p < 0.05). The DEL/DEL genotype of 45nt deletion/insertion variant polymorphism of the UCP2 gene (UCP2 DEL/INS) was associated with higher C3 (p < 0.05) than DEL/INS and INS/INS genotypes. This study provides evidence of a role of UCP2 -866G>A in modifying low-grade inflammatory state in apparently healthy children and adolescents. Given the implication of complement factors on atherosclerosis process, these results contribute to explain the reduced cardiovascular risk associated with the A allele of the UCP2 -866G>A polymorphism.

Place, publisher, year, edition, pages
Nature Publishing Group, 2009. Vol. 66, no 3, 350-354 p.
National Category
Medical and Health Sciences Pediatrics Medical Genetics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-12069DOI: 10.1203/PDR.0b013e3181b1bd35ISI: 000269339800020PubMedID: 19531977Scopus ID: 2-s2.0-70350433070OAI: oai:DiVA.org:oru-12069DiVA: diva2:355146
Available from: 2010-10-05 Created: 2010-10-05 Last updated: 2017-12-12Bibliographically approved

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Nilsson, Torbjörn K.Olsson, Lovisa A.

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