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Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease
Örebro University, School of Health and Medical Sciences.
School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.
School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Rheumatology, Danderyds hospital, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (RISPA- MEP-RG)ORCID iD: 0000-0002-9831-0896
2010 (English)In: Respiratory research (Online), ISSN 1465-9921, E-ISSN 1465-993X, Vol. 11, article id 97Article in journal (Refereed) Published
Abstract [en]

Background: It is hypothesized that decreased capillarization of limb skeletal muscle is implicated in the decreased exercise tolerance in COPD patients. We have recently demonstrated decreased number of capillaries per muscle fibre (CAF) but no changes in CAF in relation to fibre area (CAFA), which is based on the diffusion distance between the capillary and muscle fibre. The aim of the current study is to investigate the muscle-to-capillary interface which is an important factor involved in oxygen supply to the muscle that has previously been suggested to be a more sensitive marker for changes in the capillary bed compared to CAF and CAFA.

Methods: 23 COPD patients and 12 age-matched healthy subjects participated in the study. Muscle-to-capillary interface was assessed in muscle biopsies from the tibialis anterior muscle using the following parameters:

1) The capillary-to-fibre ratio (C:Fi) which is defined as the sum of the fractional contributions of all capillary contacts around the fibre

2) The ratio between C:Fi and the fibre perimeter (CFPE-index)

3) The ratio between length of capillary and fibre perimeter (LC/PF) which is also referred to as the index of tortuosity.

Exercise capacity was determined using the 6-min walking test.

Results: A positive correlation was found between CFPE-index and ascending disease severity with CFPE-index for type I fibres being significantly lower in patients with moderate and severe COPD. Furthermore, a positive correlation was observed between exercise capacity and CFPE-index for both type I and type IIa fibres.

Conclusion: It can be concluded that the muscle-to-capillary interface is disturbed in the tibialis anterior muscle in patients with COPD and that interface is strongly correlated to increased disease severity and to decreased exercise capacity in this patient group.

 

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2010. Vol. 11, article id 97
Keywords [en]
COPD, muscle-capillary interface, CFPE-index, LC/PF, tortuosity
National Category
Physiology Medical and Health Sciences
Research subject
Physiology; Medicine
Identifiers
URN: urn:nbn:se:oru:diva-12493DOI: 10.1186/1465-9921-11-97ISI: 000282550500002PubMedID: 20633289Scopus ID: 2-s2.0-77956692758OAI: oai:DiVA.org:oru-12493DiVA, id: diva2:370887
Available from: 2010-11-19 Created: 2010-11-18 Last updated: 2018-09-11Bibliographically approved
In thesis
1. Sceletal muscle characteristics and physical activity patterns in COPD
Open this publication in new window or tab >>Sceletal muscle characteristics and physical activity patterns in COPD
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. Besides abnormities within the respiratory system COPD is also associated with effects outside the lungs, so called systemic effects. One systemic effect that has been highlighted is skeletal muscle dysfunction which has also been associated with reduced exercise capacity. Apart from changes in muscle morphology, low levels of physical activity have also been suggested as a plausible mediator of reduced exercise capacity in COPD. The aim of this thesis was to study muscle morphology and physical activity patterns in patients with different degrees of COPD and to examine the associations between muscle morphology, physical activity and exercise capacity in these patients. Skeletal muscle morphology was found to shift towards a more glycolytic muscle profile in COPD patients and changes in muscle morphology were found to be correlated to disease severity and to exercise capacity. Muscle capillarization was also found to be lower in COPD compared with healthy subjects and to be correlated to disease severity and exercise capacity. When studying signalling pathways involved in muscle capillarization, an overexpression of VHL was found in patients with mild and moderate COPD compared with healthy subjects. Furthermore, COPD patients were found to be less physically active compared with healthy subjects and the level of physical activity was associated with exercise capacity.In conclusion, changes in skeletal muscle morphology and low levels of physical activity are present in COPD patients and may partly explain the lower exercise capacity observed in these patients. The more glycolytic muscle profile in COPD is suggested to be mediated by hypoxia and low levels of physical activity in this patient group. Furthermore, increased levels of VHL may lead to impaired transduction of the hypoxic signalling pathway, which may contribute to the decreased muscle capillarization observed in COPD.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2010. p. 65
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 10
Keywords
COPD, muscle morphology, muscle fibre distribution, muscle capillarization, physical activity, von Hippel-Lindau protein, exercise capacity
National Category
Social Sciences Interdisciplinary Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
urn:nbn:se:oru:diva-12341 (URN)978-91-7668-768-0 (ISBN)
Public defence
2011-01-14, Hörsal P2, Fakutetsgatan 1, Örebro universitet, Örebro, 13:00
Opponent
Supervisors
Available from: 2010-10-27 Created: 2010-10-27 Last updated: 2018-01-12Bibliographically approved

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Eliason, GabriellaAbdel-Halim, Samy M.Piehl-Aulin, KarinKadi, Fawzi

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