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Physical activity patterns in patients with different degrees of chronic obstructive pulmonary disease
Örebro University, School of Health and Medical Sciences.
Örebro University, School of Health and Medical Sciences.
Department of pheumatology, danderyds hospital, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-1067-8627
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Purpose: It has previously been suggested that exercise capacity is decreased in COPD patients and that it is associated with degree of disease. The reduced exercise capacity may plausibly be due to low levels of physical activity in this patient group. In the present study we aimed to assess exercise capacity and physical activity in different stages of COPD and to examine the associations between exercise capacity, pulmonary function and degree of physical activity.

Methods: 44 COPD patients and 17 healthy subjects participated in the study. Exercise capacity was assessed using the 6 minute walking test and physical activity was assessed using a uniaxial accelerometer worn all waking hours during seven days.

Results: Mean exercise capacity was significantly lower in COPD patients compared to healthy subjects. Mean physical activity level and time spent at least moderately active were significantly lower in patients with moderate and severe COPD compared to healthy subjects while no differences in time spent sedentary were observed between the study groups. Pulmonary function, mean physical activity level and time spent at least moderately physically active were significantly associated with exercise capacity in the patients.

Conclusions: Patients with moderate and severe COPD are significantly less physically active compared to healthy subjects. Furthermore, mean physical activity level as well as physical activity of at least moderate intensity are positively associated with exercise capacity in COPD patients while time spent sedentary is not which stresses an important role of physical activity on exercise capacity in this patient group. 

National Category
Physiology Medical and Health Sciences
Research subject
Physiology; Medicine
Identifiers
URN: urn:nbn:se:oru:diva-12495OAI: oai:DiVA.org:oru-12495DiVA, id: diva2:370902
Available from: 2010-11-18 Created: 2010-11-18 Last updated: 2018-01-12Bibliographically approved
In thesis
1. Sceletal muscle characteristics and physical activity patterns in COPD
Open this publication in new window or tab >>Sceletal muscle characteristics and physical activity patterns in COPD
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. Besides abnormities within the respiratory system COPD is also associated with effects outside the lungs, so called systemic effects. One systemic effect that has been highlighted is skeletal muscle dysfunction which has also been associated with reduced exercise capacity. Apart from changes in muscle morphology, low levels of physical activity have also been suggested as a plausible mediator of reduced exercise capacity in COPD. The aim of this thesis was to study muscle morphology and physical activity patterns in patients with different degrees of COPD and to examine the associations between muscle morphology, physical activity and exercise capacity in these patients. Skeletal muscle morphology was found to shift towards a more glycolytic muscle profile in COPD patients and changes in muscle morphology were found to be correlated to disease severity and to exercise capacity. Muscle capillarization was also found to be lower in COPD compared with healthy subjects and to be correlated to disease severity and exercise capacity. When studying signalling pathways involved in muscle capillarization, an overexpression of VHL was found in patients with mild and moderate COPD compared with healthy subjects. Furthermore, COPD patients were found to be less physically active compared with healthy subjects and the level of physical activity was associated with exercise capacity.In conclusion, changes in skeletal muscle morphology and low levels of physical activity are present in COPD patients and may partly explain the lower exercise capacity observed in these patients. The more glycolytic muscle profile in COPD is suggested to be mediated by hypoxia and low levels of physical activity in this patient group. Furthermore, increased levels of VHL may lead to impaired transduction of the hypoxic signalling pathway, which may contribute to the decreased muscle capillarization observed in COPD.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2010. p. 65
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 10
Keywords
COPD, muscle morphology, muscle fibre distribution, muscle capillarization, physical activity, von Hippel-Lindau protein, exercise capacity
National Category
Social Sciences Interdisciplinary Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
urn:nbn:se:oru:diva-12341 (URN)978-91-7668-768-0 (ISBN)
Public defence
2011-01-14, Hörsal P2, Fakutetsgatan 1, Örebro universitet, Örebro, 13:00
Opponent
Supervisors
Available from: 2010-10-27 Created: 2010-10-27 Last updated: 2018-01-12Bibliographically approved

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Eliason, GabriellaZakrisson, Ann-BrittHurtig-Wennlöf, Anita

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