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Electrical stimulation compared with tolterodine for treatment of urge/urge incontinence amongst women: a randomized controlled trial
Örebro University, School of Health and Medical Sciences. Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences. Örebro University Hospital, Örebro, Sweden; Ctr Assessment Med Technol, Örebro Cty Council, Örebro, Sweden.
Dept Urol, Torsby Hosp, Torsby, Sweden.
Dept Obstet & Gynaecol, Karlstad Hosp, Karlstad, Sweden.
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2010 (English)In: International Urogynecology Journal, ISSN 0937-3462, E-ISSN 1433-3023, Vol. 21, no 12, p. 1517-1524Article in journal (Refereed) Published
Abstract [en]

Introduction and hypothesis: Few randomized controlled trials have compared electrical stimulation treatment with drug therapy. Our hypothesis was that electrical stimulation treatment in women with urgency/urge incontinence would be more efficient compared to drug treatment.

Methods: Women ≥18 years of age with urgency/urge incontinence were randomized to receive either ten electrical stimulation treatments vaginally and transanally over a period of 5-7 weeks or tolterodine 4 mg orally once daily.

Results: Sixty-one women completed the study. There was no significant difference between the two treatment groups in micturition rate from baseline to 6 months, mean difference, -0.40 (95% confidence interval (CI), -1.61 to 0.82), but a clearly significant difference within each group for electrical stimulation, -2.8 (95% CI, -3.7 to -1.9), and for tolterodine, -3.2 (95% CI, -4.1 to -2.4).

Conclusions: Both treatments reduced the number of micturitions, but electrical stimulation was not found to be superior to tolterodine.

Place, publisher, year, edition, pages
Berlin, Germany: Springer , 2010. Vol. 21, no 12, p. 1517-1524
Keyword [en]
Electrical stimulation, pharmacological treatment, urge incontinence
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
URN: urn:nbn:se:oru:diva-12774DOI: 10.1007/s00192-010-1213-2ISI: 000285026400012PubMedID: 20585755Scopus ID: 2-s2.0-78649984938OAI: oai:DiVA.org:oru-12774DiVA, id: diva2:381043
Available from: 2010-12-22 Created: 2010-12-22 Last updated: 2018-04-19Bibliographically approved
In thesis
1. Interventions for urinary incontinence in women: survey and effects on population and patient level
Open this publication in new window or tab >>Interventions for urinary incontinence in women: survey and effects on population and patient level
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Urinary Incontinence is a common health problem that can cause both severe medical and social problems, resulting in negative impact on different aspects of Quality of Life. In 2000, the Swedish Council on Health Technology Assessment (SBU) published a systematic review, “Treatment of Urinary Incontinence” where multiple knowledge gaps in the field of UI, all of considerable clinical importance, were pointed out.Several of these knowledge gaps have been the starting points for the projects in this thesis. The overall aim has been to study the impact of different interventions for urinary incontinence in women on the population level but also on the patient group level, for assessessing the significance of UI on general living conditions and to validate instruments to measure quality of life to be used as part of the evaluation of treatment effectiveness.

Paper I: A population-based study where UI amongst women was found to be commonly associated with different psychosocial problems and an expressed feeling of vulnerability.

Paper II: A population-based study where informative material on UI to the general public in order to increase knowledge and encourage self management was found promising for meeting increasing demands and optimizing healthcare resources.

Paper III: A randomized controlled trial where both electrical stimulation and drug therapy reduced the number of micturitions and improved QoL in women with urge or urge incontinence, but electrical stimulation was not found to be superior to drug therapy.

Paper IV: A prospective cohort study where the international questionnaires UDI-6 and IIQ-7 after translation and validation, showed good responsiveness and were easy to administer and to fill out. The UDI-6 scale did not accomplish the same solid result in the psychometrical analysis as the IIQ-7 scale but both scales showed good responsiveness and can thereby be recommended for clinical use.

Place, publisher, year, edition, pages
Örebro: Örebro university, 2011. p. 74
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 51
Keyword
Urinary incontinence, female, general living conditions, self-management, electrical stimulation, quality of life questionnaire
National Category
Medical and Health Sciences Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:oru:diva-12631 (URN)978-91-7668-778-9 (ISBN)
Public defence
2011-02-11, Wilandersalen, Universitetssjukhuset, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2010-12-01 Created: 2010-12-01 Last updated: 2017-10-17Bibliographically approved

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Franzén, KarinJohansson, Jan-ErikNilsson, Kerstin

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