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Analysis of POPs in human samples reveal a contribution of brominated dioxin of up to 15% of the total dioxin TEQ
Örebro University, School of Science and Technology.ORCID iD: 0000-0002-6330-789X
Örebro University, School of Science and Technology.ORCID iD: 0000-0003-4128-8226
Örebro University, School of Science and Technology.ORCID iD: 0000-0002-4959-2807
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-6217-8857
2010 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 78, no 2, p. 113-120Article in journal (Refereed) Published
Abstract [en]

Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) were analyzed in both human adipose tissue and plasma from nine individuals, from the Swedish general population, using high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS). In addition, several other persistent organic pollutants (POPs) were determined in the same samples, including polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs). Polybrominated dibenzofurans were detected in all of the human adipose tissue samples confirming their presence in the Swedish population. The highest concentration was found for 2,3,7,8-TeBDF, ranging from 0.27 to 2.4 pg g(-1) lipid. followed by 1,2,3,7,8-PeBDF, 0.23-0.89 pg g(-1) lipid, 2,3,4,7,8-PeBDF, 0.44-0.54 pg g(-1) lipid, and 2,7/2,8-DiBDF, 0.19-0.30 pg g(-1) lipid. No PBDDs could be detected above the limit of detection (<0.02-<0.21 pg g(-1) lipid) in any of the samples. The levels of PCDD/Fs were in the range 1.79-31.5 pg toxic equivalents (TEQ) g(-1) lipid, and PBDEs were found in the 1.16-7.46 ng g(-1) lipid range. The measured chlorinated dioxins indicate decreasing human concentrations in Sweden. The toxicity equivalents (TEQ) for PBDD/Fs (0.2-0.8 pg TEQ g(-1) lipid) were found to contribute 1-15% of the total dioxin TEQ of the chlorinated dioxins and furans (5-18 pg TEQ g(-1) lipid) depending on the individual. Also PBDEs concentrations are decreasing compared to 1997-2000, but most noteworthy a shift in BDE pattern where BDE#47 is surpassed by BDE#153. The levels of PFCs are in the same range as the highest levels of the traditional POPs (sum of 60 PCBs) based on volume. These findings illustrate the importance of continuous monitoring of brominated compounds in both human and the environment. (C) 2009 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2010. Vol. 78, no 2, p. 113-120
Keywords [en]
PBDD, PBDF, TEQ, Human samples, PBDE, PFC
National Category
Environmental Sciences
Research subject
Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-13048DOI: 10.1016/j.chemosphere.2009.10.012ISI: 000272888200006OAI: oai:DiVA.org:oru-13048DiVA, id: diva2:382690
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Assessment of human exposure to per- and polyfluorinated compounds (PFCs): exposure through food, drinking water, house dust and indoor air
Open this publication in new window or tab >>Assessment of human exposure to per- and polyfluorinated compounds (PFCs): exposure through food, drinking water, house dust and indoor air
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Per- and polyfluorinated compounds (PFCs) are detected in humans worldwide but all sources of human exposure have not been fully characterized. The aim of this thesis was to evaluate the contributions from food, water, air and dust as sources for human PFC exposure in the general population.

Per- and polyfluorinated compounds (PFCs) are detected in humans worldwide but all sources of Up to 27 PFCs were determined at trace levels in blood (ng/mL), water (ng/L), foods (ng/g), dust (ng/g) and air (pg/m3) in a selected Catalan population and PFC intake was estimated from the measured PFC concentrations of the different sources of exposure.

The major compounds detected in human blood of the studied population were perfluorooctane sulfonate (PFOS; 7.6 ng/mL), perfluorohexane sulfonate (PFHxS; 3.6 ng/mL) and perfluorooctanoic acid (PFOA; 1.8 ng/mL). In general, PFOS was also the major compound detected in most sources of exposure.

Food was found to be the dominant pathway for human PFC exposure accounting for more than 70 % of the total intake of both PFOS and PFOA. In the most populated area (the Barcelona Province) where the highest levels were measured, tap water can contribute to the total exposure substantially with more than 50 % for adults. Indoor sources were negligible in the selected area for most PFCs when compared to food and water intake, except for toddlers under a worst case scenario where contribution from dust and food intake were equal (19 %).

Pharmacokinetic (PK) modelling resulted in exposure of 103 ng PFOS/day and 33 ng PFOA/day of adults from the internal PFC blood concentrations. This agrees well with the intake estimated from external exposure through food, drinking water, house dust and indoor air of 80 ng PFOS/day and 32 ng PFOA/day and evidently all major exposure sources for the general population were included (in this study).

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2011. p. 85
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 10
Keywords
human exposure, per- and polyfluorinated compunds (PFCs), dietary intake, drinking water, indoor environment
National Category
Earth and Related Environmental Sciences Environmental Sciences Chemical Sciences
Research subject
Environmental Chemistry; Chemistry
Identifiers
urn:nbn:se:oru:diva-16624 (URN)978-91-7668-811-3 (ISBN)
Public defence
2011-09-23, Örebro universitet, Hörsal M, Fakultetsgatan 1, Örebro, 10:00 (English)
Opponent
Supervisors
Available from: 2011-08-24 Created: 2011-08-24 Last updated: 2017-10-17Bibliographically approved

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Ericson Jogsten, IngridHagberg, JessikaLindström, Gunillavan Bavel, Bert

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