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Impairment of maximal aerobic power with moderate hypoxia in endurance athletes: do skeletal muscle mitochondria play a role?
Örebro University, School of Health and Medical Sciences. Serv Physiol & Explorat Fonct, Hop Civil, Strasbourg, France; Fac Med, Dept Physiol, UPRES EA3072, Strasbourg, France. (Muscle & Exercise Physiology Research Group, RISPA)ORCID iD: 0000-0002-8071-4745
UFR STAPS, Univ Strasbourg, Strasbourg, France; Serv Physiol & Explorat Fonct, Hop Civil, Strasbourg, France; Fac Med, Dept Physiol, UPRES EA3072, Strasbourg, France.
Serv Physiol & Explorat Fonct, Hop Civil, Strasbourg, France; Fac Med, Dept Physiol, UPRES EA3072, Strasbourg, France. (UPRES E.A. 3072)
Serv Physiol & Explorat Fonct, Hop Civil, Strasbourg, France; Fac Med, Dept Physiol, UPRES EA3072, Strasbourg, France. (UPRES E.A. 3072)
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2010 (English)In: American Journal of Physiology. Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, E-ISSN 1522-1490, Vol. 298, no 3, p. R558-R566Article in journal (Refereed) Published
Abstract [en]

This study investigates the role of central vs. peripheral factors in the limitation of maximal oxygen uptake ((V) over dot O-2max) with moderate hypoxia [inspired fraction (FIO2) = 14.5%]. Fifteen endurance-trained athletes performed maximal cycle incremental tests to assess (V) over dotO(2max), maximal cardiac output ((Q) over dot(max)), and maximal arteriovenous oxygen (a-vO(2)) difference in normoxia and hypoxia. Muscle biopsies of vastus lateralis were taken 1 wk before the cycling tests to evaluate maximal muscle oxidative capacity ((V) over dot(max)) and sensitivity of mitochondrial respiration to ADP (K-m) on permeabilized muscle fibers in situ. Those athletes exhibiting the largest reduction of (V) over dotO(2max) in moderate hypoxia (Severe Loss group: -18 +/- 2%) suffered from significant reductions in Q(max) (-4 +/- 1%) and maximal a-vO(2) difference (-14 +/- 2%). Athletes who well tolerated hypoxia, as attested by a significantly smaller drop of (V) over dotO(2max) with hypoxia (Moderate Loss group: -7 +/- 1%), also display a blunted (Q) over dot(max) (-9 +/- 2%) but, conversely, were able to maintain maximal a-vO(2) difference (+1 +/- 2%). Though (V) over dot(max) was similar in the two experimental groups, the smallest reduction of (V) over dotO(2max) with moderate hypoxia was observed in those athletes presenting the lowest apparent Km for ADP in the presence of creatine (K-m (+) (Cr)). In already-trained athletes with high muscular oxidative capacities, the qualitative, rather than quantitative, aspects of the mitochondrial function may constitute a limiting factor to aerobic ATP turnover when exercising at low FIO2, presumably through the functional coupling between the mitochondrial creatine kinase and ATP production. This study suggests a potential role for peripheral factors, including the alteration of cellular homeostasis in active muscles, in determining the tolerance to hypoxia in maximally exercising endurance-trained athletes.

Place, publisher, year, edition, pages
2010. Vol. 298, no 3, p. R558-R566
Keywords [en]
exercise, cardiac output
National Category
Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-13000DOI: 10.1152/ajpregu.00216.2009ISI: 000274980000006OAI: oai:DiVA.org:oru-13000DiVA, id: diva2:382858
Available from: 2011-01-03 Created: 2011-01-03 Last updated: 2018-04-20Bibliographically approved

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Ponsot, Elodie

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