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Sampling for Chlamydia trachomatis infection: a comparison of vaginal, first-catch urine, combined vaginal and first-catch urine and endocervical sampling
Dept Local Hlth Care, Linköping Univ, Linköping, Sweden; Dept Dermatol & Venereol, Linköping Univ Hosp, Linköping, Sweden.
Dept Dermatol & Venereol, Linköping Univ Hosp, Linköping, Sweden.
Ryhov Cty Hosp, Dept Dermatol & Venereol, Jönköping, Sweden.
Örebro University, School of Health and Medical Sciences. Örebro University Hospital, Örebro, Sweden.
2010 (English)In: International Journal of STD and AIDS (London), ISSN 0956-4624, E-ISSN 1758-1052, Vol. 21, no 4, p. 283-287Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to evaluate the sensitivity of patients' self-sampled vaginal specimens, first-catch urine (FCU), combined vaginal/FCU specimens and endocervical specimens for detecting chlamydial infection in women. Women attending sexually transmitted disease clinics, youth clinics and a women's health clinic were enrolled. They self-collected a vaginal specimen with two swabs, which were placed into a sterile tube and into a tube containing a buffer medium, respectively. An FCU sample was collected and aliquoted into both an empty tube and the tube containing the vaginal swab. A clinician collected an endocervical swab. The samples were sent to laboratories for analysis using polymerase chain reaction testing and strand displacement amplification testing, respectively. The sensitivities calculated in all 171 Chlamydia trachomatis-infected women were equal for endocervical specimens (97.1%), vaginal specimens (96.5%) and combined vaginal/FCU specimens (95.3%), whereas the sensitivity for FCU was significantly lower (87.7%). The sensitivity of vaginal specimens for the detection of C. trachomatis is as high as that of combined vaginal/FCU specimens.

Place, publisher, year, edition, pages
2010. Vol. 21, no 4, p. 283-287
Keywords [en]
sexually transmitted infections, vaginal sampling, chlamydia, women
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-12950DOI: 10.1258/ijsa.2009.009440ISI: 000277903600012OAI: oai:DiVA.org:oru-12950DiVA, id: diva2:383175
Available from: 2011-01-04 Created: 2011-01-03 Last updated: 2018-04-23Bibliographically approved

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Fredlund, Hans

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