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Inhalation exposure to fluorotelomer alcohols yield perfluorocarboxylates in human blood?
Örebro University, School of Science and Technology.ORCID iD: 0000-0003-3722-4633
Örebro University, School of Science and Technology.
Örebro University, School of Science and Technology.
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-6217-8857
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2010 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 44, no 19, p. 7717-7722Article in journal (Refereed) Published
Abstract [en]

Levels of perfluorinated carboxylates (PFCAs) in different environmental and biological compartments have been known for some time, but the routes of exposure still remain unclear. The opinions are divergent whether the exposure to general populations occurs mainly indirect through precursor compounds or direct via PFCAs. Previous results showed elevated blood levels of PFCAs in ski wax technicians compared to a general population. The objective of this follow-up study was to determine concentrations of PFCAs, perfluorosulfonates (PFSAs), and fluorotelomer alcohols (FTOHs), precursor compounds that are known to degrade to PFCAs, in air collected in the breathing zone of ski wax technicians during work. We collected air samples by using ISOLUTE ENV+ cartridges connected to portable air pumps with an air flow of 2.0 L min(-1). PFCAs C5-C11 and PFSAs C4, C6, C8, and C10 were analyzed using LC-MS/MS and FTOHs 6:2, 8:2, and 10:2 with GC-MS/MS. The results show daily inhalation exposure of 8:2 FTOH in mu g/m(3) air which is up to 800 times higher than levels of PFOA with individual levels ranging between 830-255000 ng/m(3) air. This suggests internal exposure of PFOA through biotransformation of 8:2 FTOH to PFOA and PFNA in humans.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2010. Vol. 44, no 19, p. 7717-7722
National Category
Chemical Sciences Environmental Sciences Biological Sciences
Research subject
Chemistry; Environmental Chemistry; Biology
Identifiers
URN: urn:nbn:se:oru:diva-12870DOI: 10.1021/es101951tISI: 000282209700086Scopus ID: 2-s2.0-77957363918OAI: oai:DiVA.org:oru-12870DiVA, id: diva2:383514
Note

Funding agency: Cancer and Allergy Foundation; Swedish Winter sport Research Center at Mid Sweden University

Available from: 2011-01-05 Created: 2011-01-03 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Occupational exposure to fluorinated ski wax
Open this publication in new window or tab >>Occupational exposure to fluorinated ski wax
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Per- and polyfluorinated substances (PFAS) are used in the production of ski wax to reduce the friction between the snow and the ski. In this occupational study of ski wax technicians’ exposure to PFAS and particulate aerosol we have collected whole blood (wb) (n =94), air (n =84) and aerosol (n =159) samples at World Cup events from 2007-2011.

We have analysed the blood, air and aerosol with respect to 13 perfluorocarboxylic acids (PFCAs), 4 perfluorosulfonic acids (PFSAs), 3 fluorotelomer alcohols (FTOHs), 3 fluorotelomer acids (FTCAs) and 3 unsaturated fluorotelomer acids (FTUCAs). Further, we assessed the exposure to 3 particulate aerosol fractions (inhalable, respirable and total aerosol) in air.

In comparison to a general population, several of the PFCA blood levels are elevated in the technicians’, primarily  erfluorooctanoate (PFOA) and perfluorononate (PFNA) with concentrations up to 628 and 163 ng/mL wb, respectively. Further,  we detected FTUCAs and FTCAs in the blood, suggesting biotransformation of FTOHs to PFCAs. The metabolites 5:3 and 7:3 FTCA were detected in all blood samples at levels up to 6.1 and 3.9 ng/mL wb. Levels of perfluorohexadecanoic acid PFHxDA) and perfluorooctadecanoic acid (PFOcDA) were detected in the technician’s blood at mean concentration up to 4.22 ng/mL wb and 4.25 ng/mL wb.

The FTOH levels in air of the wax cabin during work ranged up to 997 000 ng/m3 (average=114 000 ng/m3 ) and PFOA up to 4 890 ng/m3 (average= 526 ng/m3 . FTOHs were not detected in aerosols but PFOA showed average levels of 12 000 ng/m3 (range=1 230- 46 900 ng/m3 ).

The occupational exposure limit (OEL) of 2 mg/m3 was exceeded in 37% of the personal measurements with aerosol  concentrations up to 15 mg/m3 . Keywords : Perfluorinated, polyfluorinated, FIS, occupational exposure, ski wax,  iotransformation, metabolism, fluorotelomer alcohol, fluorotelomer acid, aerosol, dust, UPLC/MS-MS, GC/MS-MS

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2012. p. 73
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 11
Keywords
Perfluorinated, polyfluorinated, FIS, occupational exposure, ski wax, biotransformation, metabolism, fluorotelomer alcohol, fluorotelomer acid, aerosol, dust, UPLC/MS-MS, GC/MS-MS
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:oru:diva-24289 (URN)978-91-7668-887-8 (ISBN)
Public defence
2012-09-28, Hörsal P2, Prismahuset, Örebro universitet, Falultetsgatan 1, Örebro, 10:00 (English)
Opponent
Available from: 2012-08-07 Created: 2012-08-07 Last updated: 2017-10-17Bibliographically approved

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Nilsson, HelenaKärrman, AnnaRotander, Annavan Bavel, BertLindström, GunillaWestberg, Håkan

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