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Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring
Stockholm Univ, Dept Immunol, Wenner Gren Inst, Arrhenius Labs Nat Sci, S-10691 Stockholm, Sweden .
Stockholm Univ, Dept Immunol, Wenner Gren Inst, Arrhenius Labs Nat Sci, S-10691 Stockholm, Sweden .
Stockholm Univ, Dept Immunol, Wenner Gren Inst, Arrhenius Labs Nat Sci, S-10691 Stockholm, Sweden .
Stockholm Univ, Dept Immunol, Wenner Gren Inst, Arrhenius Labs Nat Sci, S-10691 Stockholm, Sweden .
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2010 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 162, no 3, p. 500-509Article in journal (Refereed) Published
Abstract [en]

Breast milk contains pro- and anti-inflammatory cytokines and chemokines with potential to influence immunological maturation in the child. We have shown previously that country of birth is associated with the cytokine/chemokine profile of breast milk. In this study we have investigated how these differences in breast milk affect the cellular response of cord blood mononuclear cells (CBMCs) and intestinal epithelial cells (IECs, cell line HT-29) to microbial challenge. Ninety-five women were included: 30 from Mali in West Africa, 32 Swedish immigrants and 33 native Swedish women. CBMCs or IECs were stimulated in vitro with breast milk, alone or in combination with lipopolysaccharide (LPS) or peptidoglycan (PGN). Breast milk in general abrogated the LPS-induced down-regulation of surface CD14 and Toll-like receptor (TLR)-4 expression on CB monocytes, while inhibiting the PGN-induced TLR-2 up-regulation. However, breast milk from immigrant women together with LPS induced a lower CBMC release of interleukin (IL)-6 (P = 0 center dot 034) and CXCL-8/IL-8 (P = 0 center dot 037) compared with breast milk from Swedish women, while breast milk from Swedish women and Mali women tended to increase the response. The same pattern of CXCL-8/IL-8 release could be seen after stimulation of IECs (HT-29). The lower CBMC and IEC (HT-29) responses to microbial compounds by breast milk from immigrant women could be explained by the fact that breast milk from the immigrant group showed a divergent pro- and anti-inflammatory content for CXCL-8/IL-8, transforming growth factor-beta 1 and soluble CD14, compared to the other two groups of women. This may have implications for maturation of their children's immune responses.

Place, publisher, year, edition, pages
Oxford, Untited Kingdom: Wiley-Blackwell Publishing Inc., 2010. Vol. 162, no 3, p. 500-509
Keyword [en]
Growth-factor-beta, pattern-recognition receptor, inflammatory-bowel-disease, soluble cd14, nonallergic mothers, atopic disease, iga production, secretory iga, ethnic-groups, cytokines
National Category
Medical and Health Sciences Clinical Medicine Pediatrics
Research subject
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-13082DOI: 10.1111/j.1365-2249.2010.04275.xISI: 000284068400012PubMedID: 20942805Scopus ID: 2-s2.0-79952472168OAI: oai:DiVA.org:oru-13082DiVA: diva2:384410
Note

Funding Agency: Swedish Research Council,74X-15160-03-2, 57X-15160-05-02. Montgomery S. M. is also affiliated to Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden and Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Dept Primary Care & Social Med, London, England

Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2017-12-11Bibliographically approved

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Schollin, JensMontgomery, Scott M.

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