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Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-7957-0310
2009 (English)In: Canadian journal of urology, ISSN 1195-9479, Vol. 16, no 6, p. 4901-4907Article in journal (Refereed) Published
Abstract [en]

Introduction/objective: Cranberries have been shown to produce urinary metabolites that influence uropathogen adhesion and prevent urinary tract infections. This study was designed to determine if consuming reconstituted, unsweetened cranberry drink from extract retained its bioactive properties by reducing uropathogen adhesion without adversely affecting urinary calcium, magnesium and the vaginal microflora. Materials and methods: A randomized crossover study Was undertaken in 12 healthy Women consuming reconstituted unsweetened cranberry drink, CranActin or Water. The urine was collected at 4 hours and 1 week of consumption and evaluated for antiadhesive properties and urinary pH, calcium and magnesium. Vaginal swabs Were collected after 1 Week of treatment to assess the vaginal microbiota by DGGE. Results: The resultant urine produced by subjects who consumed 500 ml reconstituted cranberry extract twice per day, significantly reduced the adherence to epithelial cells of P-fimbriated uropathogenic Escherichia coli and showed a tendency towards significance for two E. coli strains expressing fimbriae and an Enterococcus faecalis isolate. The cranberry drink treatment did not alter urinary pH, but reduced calcium and magnesium concentrations compared to Water, although not to statistical significance. The reconstituted cranberry drink may retain the ability to effect on the vaginal microbiota. However, consuming twice daily resulted in an apparent loss of a potential pathogen from the vagina in 42% subjects. Conclusions: The present findings suggest that reconstituted cranberry drink may retain the ability to reduce the risk of UTI by inhibiting pathogen adhesion While not detrimentally affecting urinary pH or vaginal microbiota, or the risk of calculi.

Place, publisher, year, edition, pages
Baie d'Urfé, Quebec: Rodar Publishing. , 2009. Vol. 16, no 6, p. 4901-4907
Keywords [en]
vaginal microbiota, cranberry drink, urinary tract infections, fimbriae adhesins, Escherichia coli, Enterococcus faecalis
National Category
Biological Sciences
Research subject
Biology
Identifiers
URN: urn:nbn:se:oru:diva-13161ISI: 000272741200006OAI: oai:DiVA.org:oru-13161DiVA, id: diva2:386015
Available from: 2011-01-12 Created: 2011-01-11 Last updated: 2017-10-18Bibliographically approved

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Jass, Jana

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CiteExportLink to record
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