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Computational evidence for the role of Arabidopsis thaliana UVR8 as UV-B photoreceptor and identification of its chromophore amino acids
National University of Ireland, Galway, Ireland.
Örebro University, School of Science and Technology. (Biokemi)
National University of Ireland, Galway, Ireland.
Örebro University, School of Science and Technology. (Biokemi)ORCID iD: 0000-0003-3315-8835
2011 (English)In: Journal of Chemical Information and Modeling, ISSN 1549-9596, E-ISSN 1549-960X, Vol. 51, no 6, p. 1287-1295Article in journal (Refereed) Published
Abstract [en]

A homology model of the Arabidopsis thaliana UV resistance locus 8 (UVR8) protein is presented herein, showing a seven-bladed β-propeller conformation similar to the globular structure of RCC1. The UVR8 amino acid sequence contains a very high amount of conserved tryptophans, and the homology model shows that seven of these tryptophans cluster at the 'top surface’ of the UVR8 protein where they are intermixed with positive residues (mainly arginines) and a couple of tyrosines. Quantum chemical calculations of excitation spectra of both a large cluster model involving all twelve above-mentioned residues and smaller fragments thereof reveal that absorption maxima appearing in the 280-300 nm range for the full cluster result from interactions between the central tryptophans and surrounding arginines. This observation coincides with the published experimentally measured action spectrum for the UVR8-dependent UVB stimulation of HY5 transcription in mature A. thaliana leaf tissue. In total these findings suggest that UVR8 has in fact in itself the ability to be an ultraviolet-B photoreceptor in plants.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2011. Vol. 51, no 6, p. 1287-1295
National Category
Biochemistry and Molecular Biology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-15766DOI: 10.1021/ci200017fISI: 000292010100009PubMedID: 21561100OAI: oai:DiVA.org:oru-15766DiVA, id: diva2:420543
Available from: 2012-08-07 Created: 2011-06-01 Last updated: 2018-09-05Bibliographically approved

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Grahn, Elin M.Strid, Åke

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