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Aberrant tyrosine transport across the fibroblast membrane in patients with schizophrenia: indications of maternal inheritance
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-8102-1804
2011 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 45, no 4, p. 519-525Article in journal (Refereed) Published
Abstract [en]

Background: In previous studies of the present patients with schizophrenia, aberrant tyrosine transport across the fibroblast membrane was found. A low K(m), a kinetic factor indicating high affinity between tyrosine and the binding site at the cell membrane, was found to be associated with poor cognitive functions in patients. The present study aimed at investigating possible relationships between patients with schizophrenia and their first-degree relatives in aberrant tyrosine transport indicating that it may be a biological marker for the genetic susceptibility. Methods: Thirty-three parents, 13 fathers and 20 mothers, from 23 families with a schizophrenic patient agreed to enter the study. They underwent skin biopsies for fibroblast cultivation, neuropsychological and psychiatric investigations and were classified as family history positive or negative. Tyrosine transport kinetics (K(m) and V(max)) were calculated from in vitro trials of gradients of extracellular tyrosine concentrations in fibroblast cultures. Results: An association between patients with schizophrenia and their mothers were found for a low K(m) indicating maternal inheritance. Mothers displaying a low K(m) performed worse on the neuropsychological tests compared to mothers with normal K(m). Corresponding relationships between a low K(m) and neurocognitive dysfunction had previously been found for the patients. Conclusions: An aberrant tyrosine transport across plasma membrane may constitute a biological marker for an endophenotype within the schizophrenia spectrum with low cognitive functioning. A plausible mode for genetic transmission is maternal inheritance. (C) 2010 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Pergamon Press, 2011. Vol. 45, no 4, p. 519-525
Keywords [en]
Tyrosine transport, Schizophrenia, Maternal inheritance, Cognitive dysfunction, Endophenotype
National Category
Medical and Health Sciences
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-17084DOI: 10.1016/j.jpsychires.2010.08.001ISI: 000289325900013PubMedID: 20728902Scopus ID: 2-s2.0-79952621642OAI: oai:DiVA.org:oru-17084DiVA, id: diva2:438927
Available from: 2011-09-06 Created: 2011-09-02 Last updated: 2017-12-08Bibliographically approved

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Venizelos, Nikolaos

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CiteExportLink to record
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Citation style
  • apa
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