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Unfavourable outcome for women in a study of health-related quality of life, social factors and work disability in Crohn’s disease
Div Gastroenterol & Hepatol, Dept Clin & Expt Med, Linköping Univ, Linköping, Sweden.
Örebro University, School of Health and Medical Sciences.
Div Gastroenterol & Hepatol, Dept Clin & Expt Med, Linköping Univ, Linköping, Sweden.
Div Gastroenterol & Hepatol, Dept Clin & Expt Med, Linköping Univ, Linköping, Sweden.
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2011 (English)In: European Journal of Gastroenterology and Hepathology, ISSN 0954-691X, E-ISSN 1473-5687, Vol. 23, no 8, p. 671-679Article in journal (Refereed) Published
Abstract [en]

Objective The aim was to describe health-related quality of life (HRQL) and social factors, sickness and disability variables in a large population-based cohort of patients with Crohn’s disease (CD). Methods HRQL was measured with Short Form-36 in 497 adult patients with CD at three outpatient clinics. Comparisons were made with age-sex-matched background population and with ulcerative colitis (UC). Social factors, employment, sickness compensation and disability pension for CD were compared with national population registers. Results CD had a greater negative effect on HRQL than did UC. This difference was more pronounced for women. Compared with background population, patients with CD had lower educational level, and had a two-fold rise in long-term sickness and disability pension rate. Women with CD had higher rates of sickness and disability than men with CD and were more often living single, though procreation was not affected. Conclusion This study characterized the burden of CD in a large population-based cohort. CD had higher impact on HRQL, compared with UC. Women with CD had worse outcome in subjective health status, but not in objective assessment of disease activity. Women also had higher rates of sickness, disability pension and single living. The mechanism underlying the sex-related inequalities in outcome for CD warrants further elucidation. Eur J Gastroenterol Hepatol 23: 671-679 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Place, publisher, year, edition, pages
2011. Vol. 23, no 8, p. 671-679
Keywords [en]
Crohn’s disease, disability, health-related quality of life, inflammatory bowel disease, sickness, social factors
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-17034DOI: 10.1097/MEG.0b013e328346f622ISI: 000292503100006PubMedID: 21654323OAI: oai:DiVA.org:oru-17034DiVA, id: diva2:439346
Available from: 2011-09-07 Created: 2011-09-02 Last updated: 2018-05-03Bibliographically approved

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