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Death of photoreceptors in organotypic retinal explant cultures: implication of rhodopsin accumulation and endoplasmic reticulum stress
Örebro University, School of Health and Medical Sciences.
2011 (English)In: Journal of Neuroscience Methods, ISSN 0165-0270, E-ISSN 1872-678X, Vol. 197, no 1, p. 56-64Article in journal (Refereed) Published
Abstract [en]

Here we suggest that endoplasmic reticulum (ER)-stress may be induced following aberrant rhodopsin accumulation in photoreceptors in explanted rat retinas. Rhodopsin accumulation was accompanied by increased phosphorylation of pancreatic ER-kinase and eukaryotic initiator factor 2 alpha as well as increased levels of C/EBP homologous protein, glucose-regulated protein 78 and eventually increased cleaved caspase-12 and cleaved caspase-3. Glucose-regulated protein 78, pancreatic ER-kinase, caspase-12 and cleaved caspase-3 were present in photoreceptors, indicating that ER-stress and apoptosis are induced in this cell population. These results suggest that ER-stress and subsequent apoptosis is induced in healthy photoreceptors, presumably by aberrant accumulation of rhodopsin and the phosphorylation of eukaryotic initiator factor 2 alpha. The explant culture system may allow investigations of neuroprotective strategies. (C) 2011 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2011. Vol. 197, no 1, p. 56-64
National Category
Medical and Health Sciences
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-17557DOI: 10.1016/j.jneumeth.2011.01.030ISI: 000290075000007OAI: oai:DiVA.org:oru-17557DiVA, id: diva2:444363
Available from: 2011-09-28 Created: 2011-09-28 Last updated: 2017-12-08Bibliographically approved

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Johansson, Kjell

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