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Human papillomavirus prevalence, distribution and correlation to histopathological parameters in a large Swedish cohort of men with penile carcinoma
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-2317-5738
Örebro University Hospital, Örebro, Sweden.
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2011 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 108, no 3, p. 355-359Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE To analyse the overall and type-specific human papillomavirus (HPV) prevalence and distribution in penile carcinoma and determine the correlation to histopathological parameters.

PATIENTS AND METHODS In this retrospective study, we analysed HPV status in 241 patients with penile carcinoma, treated at Orebro University Hospital, Orebro, Sweden, between 1984 and 2008. Age and date at diagnosis was recorded. The tumour specimens were categorized according to the UICC 2002 TNM classification. A subset of patients was operatively staged with regard to lymph node status. A commercially available Real Time PCR was used to detect 13 different types of HPV (6,11,16,18,31,33,35,45,51,52,56,58 and 59).

RESULTS We excluded 25 patients due to low DNA quality. Of the remaining 216, 179 (82.9%) tumour specimens were HPV infected. The majority of cases positive for HPV (70.4%) were infected by a single-type. The most frequent type was HPV 16 followed by HPV 18. No significant association between HPV status and pathological tumour stage, grade or lymph node status was found.

CONCLUSION The HPV prevalence found is higher than in most other studies, further strengthening HPV as an etiological agent in penile carcinoma. Furthermore, the high prevalence of HPV 16 and 18 raises the question of what potential impact current HPV vaccines that target these specific HPV types might have on penile carcinoma. No significant association between HPV status and histopathological parameters was found in the present study. Additional investigations are needed to draw final conclusions on the prognostic value of HPV status in penile carcinoma.

Place, publisher, year, edition, pages
2011. Vol. 108, no 3, p. 355-359
National Category
Medical and Health Sciences
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-18676DOI: 10.1111/j.1464-410X.2010.09770.xISI: 000293007800013PubMedID: 21044240Scopus ID: 2-s2.0-79960606053OAI: oai:DiVA.org:oru-18676DiVA, id: diva2:444837
Available from: 2011-09-30 Created: 2011-09-29 Last updated: 2018-05-03Bibliographically approved
In thesis
1. Penile cancer: studies on prognostic factors
Open this publication in new window or tab >>Penile cancer: studies on prognostic factors
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2014. p. 77
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 108
Keywords
Human papillomavirus, Incidence, Penile cancer, Prognostic factors, Recurrences, Sentinel node, Survival
National Category
Medical and Health Sciences Surgery
Research subject
Medicine; Surgery
Identifiers
urn:nbn:se:oru:diva-35379 (URN)978-91-7529-002-7 (ISBN)
Public defence
2014-09-26, Universitetssjukhuset, Wilandersalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
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Supervisors
Available from: 2014-06-17 Created: 2014-06-17 Last updated: 2017-10-17Bibliographically approved

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Kirrander, PeterHelenius, GiselaAndrén, OveLillsunde-Larsson, GabriellaElgh, FredrikKarlsson, Mats G.

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