oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of genetic determinant in the development of severe perinatal asphyxia
Dept Med Genet, Natl Med Acad Postgrad Educ, Kiev, Ukraine.
Reference Ctr Mol Diagnost, Minist Publ Hlth Ukraine, Kiev, Ukraine.
Dept Med Genet, Natl Med Acad Postgrad Educ, Kiev, Ukraine.
Dept Paediat, Ukrainian Stomatol Acad, Poltava, Ukraine.
Show others and affiliations
2010 (English)In: Cytology and genetics, ISSN 0095-4527, Vol. 44, no 5, p. 294-299Article in journal (Refereed) Published
Abstract [en]

The frequency of GSTT1 and GSTM1 gene deletion polymorphism was determined in a case-control study of full-term Ukrainian newborns including patients with perinatal asphyxia. Multiplex polymerase chain reaction was used for genotyping 245 full-term newborns. The investigated full-term newborns with perinatal asphyxia were subdivided in the subgroups depending of severity of perinatal asphyxia and neonatal outcome. No significant differences in allele frequencies of homozygous null genotypes of GSTT1 and GSTM1 gene were detected among newborns with moderate perinatal asphyxia and healthy control. However, association with the development of severe perinatal asphyxia was detected for the deletion polymorphism in GSTT1 gene and the combination of the GSTT1 absent/GSTM1 absent in the newborns. The study shows that severe perinatal asphyxia may develop in the consequence of genetic predisposition to this condition as compare with moderate.

Place, publisher, year, edition, pages
Springer International Publishing AG , 2010. Vol. 44, no 5, p. 294-299
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-18892DOI: 10.3103/S0095452710050063ISI: 000288439800006OAI: oai:DiVA.org:oru-18892DiVA, id: diva2:445578
Available from: 2011-10-04 Created: 2011-09-30 Last updated: 2018-04-24Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Lundberg, Gunilla A.

Search in DiVA

By author/editor
Lundberg, Gunilla A.
By organisation
School of Health and Medical Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 175 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf