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Release of corticotropin after administration of corticotropin-releasing hormone in depressed patients in relation to the dexamethasone suppression test
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-1592-8835
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1993 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 87, no 2, p. 133-140Article in journal (Refereed) Published
Abstract [en]

The possible hypersecretion involvement of corticotropin-releasing hormone (CRH) in the pathophysiology of hypothalamic-pituitary-adrenocortical axis disturbances in patients with major depressive episode and with an abnormal dexamethasone suppression test (DST) was investigated. The corticotropin (ACTH) and cortisol response to the injection of 45 micrograms of synthetic human CRH at 1630 were analyzed in 24 inpatients with normal (suppressors) or abnormal (nonsuppressors) DST. The outcome of the DST was analyzed using 3 cut-off points for the cortisol levels. The clinical assessments included two rating scales. The results showed that nonsuppressors had a significantly lower ACTH response to CRH stimulation than suppressors at all cut-off points (calculated as net area under the curve and as the difference between the peak and the baseline level) despite no significant differences in the severity of depression.

Place, publisher, year, edition, pages
1993. Vol. 87, no 2, p. 133-140
National Category
Medical and Health Sciences
Research subject
Medicine
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URN: urn:nbn:se:oru:diva-20225PubMedID: 8383420OAI: oai:DiVA.org:oru-20225DiVA, id: diva2:452876
Available from: 2011-10-31 Created: 2011-10-29 Last updated: 2017-12-08Bibliographically approved

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Akner, Gunnar

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