oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-1592-8835
1995 (English)In: Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, E-ISSN 1879-1220, Vol. 52, no 1, p. 1-16Article in journal (Refereed) Published
Abstract [en]

The cellular distribution of the glucocorticoid receptor (GR) has not yet been firmly established. The extensive literature indicates that GR is present both in the cytoplasm and the cell nucleus, however, some studies have failed to detect cytoplasmic GR. It is still controversial as to whether GR is randomly diffusing in the cytoplasm and nucleus, or if the GR-distribution is organized or controlled in some way, which may be of importance for the transduction of glucocorticoid effects to cells. There is evidence that both non-activated and activated GR is associated with the plasma membrane, a number of cytoplasmic organelles and the nucleus. Both morphological and biochemical evidence show that GR is associated with microtubules during different stages of the cell cycle, i.e. GR co-localizes, co-purifies and co-polymerizes with tubulin. This indicates that GR is structurally linked to the intracellular MT-network which may be of importance in the mechanism of action of glucocorticoid hormones. The literature in this field is reviewed including the reported data on subcellular GR-localization.

Place, publisher, year, edition, pages
1995. Vol. 52, no 1, p. 1-16
National Category
Medical and Health Sciences
Research subject
Cell Research
Identifiers
URN: urn:nbn:se:oru:diva-20222PubMedID: 7857868OAI: oai:DiVA.org:oru-20222DiVA, id: diva2:452879
Available from: 2011-10-31 Created: 2011-10-29 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

PubMed

Authority records BETA

Akner, Gunnar

Search in DiVA

By author/editor
Akner, Gunnar
By organisation
School of Health and Medical Sciences
In the same journal
Journal of Steroid Biochemistry and Molecular Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 45 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf