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Glucocorticoid receptor inhibits microtubule assembly in vitro
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-1592-8835
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1995 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 110, no 1-2, p. 49-54Article in journal (Refereed) Published
Abstract [en]

The effect of glucocorticoid hormones, purified glucocorticoid receptor (GR) and purified heat shock protein M(r) 90,000 (hsp90) on microtubule (MT) assembly in vitro was tested by a spectrophotometric MT assembly assay and electron microscopy. GR significantly prolonged the nucleation phase, slowed down the assembly rate and reduced the maximal amplitude of MT assembly compared with control. The effects were partially reversed by the addition of glucocorticoid hormone. GR associated with MTs. These results indicate that GR affects MT assembly in vitro, which may be a functional correlate to the structural association of GR with MTs. This implies that factors affecting GR may affect MT assembly in vivo.

Place, publisher, year, edition, pages
1995. Vol. 110, no 1-2, p. 49-54
National Category
Medical and Health Sciences
Research subject
Cell Research
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URN: urn:nbn:se:oru:diva-20219PubMedID: 7672453OAI: oai:DiVA.org:oru-20219DiVA, id: diva2:452884
Available from: 2011-10-31 Created: 2011-10-29 Last updated: 2017-12-08Bibliographically approved

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Akner, Gunnar

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