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Further assessment of neuropathology in retinal explants and neuroprotection by human neural progenitor cells
Örebro University, School of Health and Medical Sciences.
2011 (English)In: Journal of Neural Engineering, ISSN 1741-2560, E-ISSN 1741-2552, Vol. 8, no 6, p. 066012-Article in journal (Refereed) Published
Abstract [en]

Explanted rat retinas show progressive photoreceptor degeneration that appears to be caspase-12-dependent. Decrease in photoreceptor density eventually affects the inner retina, particularly in the bipolar cell population. Explantation and the induced photoreceptor degeneration are accompanied by activation of Muller and microglia cells. The goal of this study was to determine whether the presence of a feeder layer of human neural progenitor cells (hNPCs) could suppress the degenerative and reactive changes in the explants. Immunohistochemical analyses showed considerable sprouting of rod photoreceptor axon terminals into the inner retina and reduced densities of cone and rod bipolar cells. Both sprouting and bipolar cell degenerations were significantly lower in retinas cultured with feeder layer cells compared to cultured controls. A tendency toward reduced microglia activation in the retinal layers was also noted in the presence of feeder layer cells. These results indicate that hNPCs or factors produced by them can limit the loss of photoreceptors and secondary injuries in the inner retina. The latter may be a consequence of disrupted synaptic arrangement.

Place, publisher, year, edition, pages
2011. Vol. 8, no 6, p. 066012-
National Category
Biomedical Laboratory Science/Technology
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-20779DOI: 10.1088/1741-2560/8/6/066012ISI: 000297684400025OAI: oai:DiVA.org:oru-20779DiVA, id: diva2:475663
Available from: 2012-01-11 Created: 2012-01-11 Last updated: 2018-02-14Bibliographically approved

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Johansson, Kjell

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