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Risk of prostate cancer in a population-based cohort of men with coeliac disease
Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-1024-5602
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Epidemiology, Harvard School of Public Health, Boston, US. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0002-3649-2639
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Primary Care and Public Health, Charing Cross Hospital, Imperial College, London, UK. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0001-6328-5494
2012 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 106, no 1, p. 217-221Article in journal (Refereed) Published
Abstract [en]

Background: Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk. METHODS: We identified 10 995 patients with CD who had undergone a small intestinal biopsy in 1969-2007. Statistics Sweden then identified 54 233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis. RESULTS: During follow-up, 185 individuals with CD (expected = 200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79-1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100 000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy. CONCLUSION: Our conclusion is that a CD diagnosis does not represent an increased risk for PC. 

Place, publisher, year, edition, pages
London, United Kingdom: Nature Publishing Group, 2012. Vol. 106, no 1, p. 217-221
Keywords [en]
Coeliac disease, cohort study, inflammation, prostate
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-21714DOI: 10.1038/bjc.2011.536ISI: 000299168300030PubMedID: 22134505Scopus ID: 2-s2.0-84855348663OAI: oai:DiVA.org:oru-21714DiVA, id: diva2:504972
Note

Available from: 2012-02-22 Created: 2012-02-20 Last updated: 2018-07-22Bibliographically approved

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Ludvigsson, Jonas F.Fall, KatjaMontgomery, Scott M.

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