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Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Örebro University, School of Science and Technology. (Man-Technology-Environment (MTM))ORCID iD: 0000-0001-6217-8857
Örebro University, School of Science and Technology. (Man-Technology-Environment (MTM))ORCID iD: 0000-0001-5752-4196
Department of Medicine, Uppsala University, Uppsala, Sweden.
2012 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 120, no 1, p. 38-43Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND OBJECTIVE: Increased circulating levels of persistent organic pollutants (POPs) have been associated with myocardial infarction. Because myocardial infarction is an atherosclerotic disease, we investigated, in a cross-sectional study, whether POP levels are related to atherosclerosis.

METHODS: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1,016 participants 70 years of age), the prevalence of carotid artery plaques was determined by ultrasound. The number of carotid arteries with plaques (0, 1, or 2) was recorded. Also, the intima-media thickness (IMT) and gray scale median of the intima-media complex (IM-GSM) were measured. Twenty-three POPs, comprising 16 polychlorinated biphenyls (PCBs), 5 pesticides, 1 dioxin, and 1 brominated compound (brominated diphenyl ether congener BDE-47), were analyzed by high-resolution chromatography coupled to high-resolution mass spectrometry.

RESULTS: Seven of the POPs (PCB congeners 153, 156, 157, 170, 180, 206, and 209) were significantly associated with the number of carotid arteries with plaques even after adjusting for multiple risk factors (sex, waist circumference, body mass index, fasting blood glucose, systolic and diastolic blood pressure, high-density lipoprotein and low-density lipoprotein cholesterol, serum triglycerides, smoking, antihypertensive treatment, and statin use; p = 0.002-0.0001). Highly chlorinated PCBs (congeners 194, 206, and 209) were associated with an echolucent IM-GSM (p < 0.0001 after adjustment), whereas associations between POPs and IMT were modest.

CONCLUSIONS: Circulating levels of PCBs were associated with atherosclerotic plaques and echogenicity of the intima-media complex independent of cardiovascular risk factors, including lipids. This suggests that POPs may be a risk factor for myocardial infarction, but associations need to be confirmed in prospective studies.

Place, publisher, year, edition, pages
Public Health Services, US Dept of Health and Human Services , 2012. Vol. 120, no 1, p. 38-43
Keywords [en]
atherosclerosis, atherosclerotic plaques, persistent organic pollutants (POPs), pesticides
National Category
Chemical Sciences
Research subject
Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-21835DOI: 10.1289/ehp.1103563ISI: 000299650400023PubMedID: 22222676Scopus ID: 2-s2.0-84855247551OAI: oai:DiVA.org:oru-21835DiVA, id: diva2:505907
Funder
Swedish Research Council
Note

Funding Agency:

Swedish Research Council for Environment, Agricultural Sciences, and Spatial Planning

Available from: 2012-02-27 Created: 2012-02-27 Last updated: 2017-12-07Bibliographically approved

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van Bavel, BertSalihovic, Samira

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