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Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom; Department of Sport Medicine, Norwegian School of Sport Science, Oslo, Norway .
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom .
College of Kinesiology, University of Saskatchewan, Saskatoon, Canada; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
College of Kinesiology, University of Saskatchewan, Saskatoon, Canada; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
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2012 (English)In: Journal of the American Medical Association (JAMA), ISSN 0098-7484, E-ISSN 1538-3598, Vol. 307, no 7, p. 704-712Article in journal (Refereed) Published
Abstract [en]

Context: Sparse data exist on the combined associations between physical activity and sedentary time with cardiometabolic risk factors in healthy children.

Objective: To examine the independent and combined associations between objectively measured time in moderate- to vigorous-intensity physical activity (MVPA) and sedentary time with cardiometabolic risk factors.

Design, Setting, and Participants: Pooled data from 14 studies between 1998 and 2009 comprising 20 871 children (aged 4-18 years) from the International Children's Accelerometry Database. Time spent in MVPA and sedentary time were measured using accelerometry after reanalyzing raw data. The independent associations between time in MVPA and sedentary time, with outcomes, were examined using meta-analysis. Participants were stratified by tertiles of MVPA and sedentary time.

Main Outcome Measures: Waist circumference, systolic blood pressure, fasting triglycerides, high-density lipoprotein cholesterol, and insulin.

Results: Times (mean [SD] min/d) accumulated by children in MVPA and being sedentary were 30 (21) and 354 (96), respectively. Time in MVPA was significantly associated with all cardiometabolic outcomes independent of sex, age, monitor wear time, time spent sedentary, and waist circumference (when not the outcome). Sedentary time was not associated with any outcome independent of time in MVPA. In the combined analyses, higher levels of MVPA were associated with better cardiometabolic risk factors across tertiles of sedentary time. The differences in outcomes between higher and lower MVPA were greater with lower sedentary time. Mean differences in waist circumference between the bottom and top tertiles of MVPA were 5.6 cm (95% CI, 4.8-6.4 cm) for high sedentary time and 3.6 cm (95% CI, 2.8-4.3 cm) for low sedentary time. Mean differences in systolic blood pressure for high and low sedentary time were 0.7 mm Hg (95% CI, -0.07 to 1.6) and 2.5 mmHg (95% CI, 1.7-3.3), and for high-density lipoprotein cholesterol, differences were -2.6 mg/dL(95% CI, -1.4 to -3.9) and -4.5 mg/dL(95% CI, -3.3 to -5.6), respectively. Geometric mean differences for insulin and triglycerides showed similar variation. Those in the top tertile of MVPA accumulated more than 35 minutes per day in this intensity level compared with fewer than 18 minutes per day for those in the bottom tertile. In prospective analyses (N=6413 at 2.1 years' follow-up), MVPA and sedentary time were not associated with waist circumference at follow-up, but a higher waist circumference at baseline was associated with higher amounts of sedentary time at follow-up.

Conclusion: Higher MVPA time by children and adolescents was associated with better cardiometabolic risk factors regardless of the amount of sedentary time.

Place, publisher, year, edition, pages
Chicago, USA: American Medical Association , 2012. Vol. 307, no 7, p. 704-712
National Category
Medical and Health Sciences Pediatrics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-21936DOI: 10.1001/jama.2012.156ISI: 000300278500027PubMedID: 22337681Scopus ID: 2-s2.0-84860711904OAI: oai:DiVA.org:oru-21936DiVA, id: diva2:507406
Available from: 2012-03-05 Created: 2012-03-05 Last updated: 2017-12-07Bibliographically approved

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Ekelund, Ulf

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