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Acute effects on the ventricular function in Swedish snuffers: an echocardiographic study
Department of Clinical Physiology, Örebro University Hospital, Örebro, Sweden.
Department of Clinical Physiology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-4262-6373
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Physiology, Örebro University Hospital, Örebro, Sweden.
2012 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 32, no 2, p. 106-113Article in journal (Refereed) Published
Abstract [en]

Aims: Cigarettes and Swedish snuff contain nicotine, which influence the cardiovascular system. Cigarette smoke has been shown to give an acute impairment in diastolic heart parameters. The systolic and diastolic heart function in snuff users is not thoroughly enough investigated. The aim of this study was to investigate if Swedish snuff will give an acute decrease in systolic and diastolic heart parameters in the left and right ventricles in healthy Swedish snuffers.

Methods and results: Thirty healthy volunteers were examined with echocardiography. The study involved recordings from four different times: before snuff intake, 5 and 30 min after intake and finally 30 min after snuff withdrawal. The systolic and diastolic heart parameters were collected with conventional echocardiographic methods. In addition, the heart frequency and blood pressure response were measured. The pulse and blood pressure response were significantly altered (P<0Æ01) during the test. Left ventricular ejection fraction and the amplitudes of mitral and tricuspid annulus motion did not alter significantly. The main finding in the study was the significant decrease (P<0Æ05) in several diastolic heart parameters for both the left and right ventricles.

Conclusions: This study shows that snuff intake causes a significant decrease in E ⁄ A ratio and a delay in ventricular relaxation and therefore a decrease in diastolic heart function in the left and right ventricles. The mechanism behind these alterations is probably very complex, but a combination of nicotine effects and loading conditions is probably the main factor.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2012. Vol. 32, no 2, p. 106-113
Keywords [en]
Doppler, echocardiography, snuff, systolic and diastolic function, tissue Doppler imaging
National Category
Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
URN: urn:nbn:se:oru:diva-21935DOI: 10.1111/j.1475-097X.2011.01062.xISI: 000299734400005PubMedID: 22296630Scopus ID: 2-s2.0-84856409031OAI: oai:DiVA.org:oru-21935DiVA, id: diva2:507407
Note

© 2011 The AuthorsClinical Physiology and Functional Imaging 2011 Scandinavian Society of Clinical Physiology and Nuclear Medicine 32, 2, 106–113

Available from: 2012-03-05 Created: 2012-03-05 Last updated: 2018-02-07Bibliographically approved

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Waldenborg, MicaelEmilsson, Kent

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