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Assessment of systemic inflammation markers to differentiate a stable from a deteriorating clinical course in patients with febrile neutropenia
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2005 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 74, no 4, p. 297-303Article in journal (Refereed) Published
Abstract [en]

In this study, we evaluated the predictive values of procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA) for determining the clinical course in febrile neutropenic patients. Daily plasma analyses during the fever course were performed in 101 episodes with fever and chemotherapy-induced neutropenia (neutrophil count <0.5 x 10(9)/L). Procalcitonin (PCT) and IL-6 values were significantly higher in febrile episodes in patients who developed complications. Procalcitonin with a cut-off value of < or =0.4 ng/mL or IL-6 < or =50 pg/mL 3 d after fever onset indicated daily high negative predictive values (NPVs) (91-100%) for episodes with complications. No marker could predict deterioration; however, daily low plasma concentrations of PCT or IL-6 during the first 8 d of fever were found to be a good predictor of no subsequent complications in neutropenic patients and therefore to be a helpful tool for limiting anti-microbial therapy.

Place, publisher, year, edition, pages
2005. Vol. 74, no 4, p. 297-303
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Clinical Medicine
Research subject
Medicine
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URN: urn:nbn:se:oru:diva-22583DOI: 10.1111/j.1600-0609.2004.00387.xOAI: oai:DiVA.org:oru-22583DiVA, id: diva2:516609
Available from: 2012-04-18 Created: 2012-04-18 Last updated: 2017-12-07Bibliographically approved

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Tidefelt, Ulf

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Citation style
  • apa
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  • Other locale
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