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Source of inflammatory markers in patients with atrial fibrillation
Department of Cardiology, University Hospital Linköping, 581 85 Linköp.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Department of Cardiology, University Hospital Linköping, 581 85 Linköp.
Department of Cardiology, University Hospital Örebro, Örebro, Sweden.
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2008 (English)In: Europace, ISSN 1099-5129, E-ISSN 1532-2092, Vol. 10, p. 848-853Article in journal (Refereed) Published
Abstract [en]

Aims Elevated levels of C-reactive protein and other inflammatory markers have been reported in some patients with atrial fibrillation (AF). Whether this finding is related to AF per se or to other conditions remains unclear. In addition, the source of inflammatory markers is unknown. Therefore, in the present study, we sought to assess the extent and the source of inflammation in patients with AF and no other concomitant heart or inflammatory conditions.

Methods and results The study group consisted of 29 patients referred for radiofrequency catheter ablation: 10 patients with paroxysmal AF, 8 patients with permanent AF, and 10 control patients with Wolf-Parkinson-White (WPW) syndrome and no evidence of AF (mean age 54±11 vs. 57±13 vs. 43±16). No patient had structural heart diseases or inflammatory conditions. High-sensitive C-reactive protein, interleukin-6 (IL-6), and interleukin-8 (IL-8) were assessed in blood samples from the femoral vein, right atrium, coronary sinus, and the left and right upper pulmonary veins. All samples were collected before ablation. Compared with controls and patients with paroxysmal AF, patients with permanent AF had higher plasma levels of IL-8 in the samples from the femoral vein, right atrium, and coronary sinus, but not in the samples from the pulmonary veins (median values in the femoral vein: 2.58 vs. 2.97 vs. 4.66 pg/mL, P = 0.003; right atrium: 2.30 vs. 3.06 vs. 3.93 pg/mL, P = 0.013; coronary sinus: 2.85 vs. 3.15 vs. 4.07, P = 0.016). A high-degree correlation existed between the IL-8 levels in these samples (correlation coefficient between 0.929 and 0.976, P< 0.05). No differences in the C-reactive protein and IL-6 levels were noted between the three groups of patients.

Conclusion The normal levels of C-reactive protein and IL-6, alongwith the elevated levels of IL-8 in patients with permanent AF but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF. The elevated IL-8 levels in the peripheral blood, right atrium, and coronary sinus but not in the pulmonary veins suggest a possible source of inflammation in the systemic circulation.

Place, publisher, year, edition, pages
Oxford University Press, 2008. Vol. 10, p. 848-853
Keywords [en]
Atrial fibrillation, Inflammation, Catheter ablation
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-22941DOI: 10.1093/europace/eun111OAI: oai:DiVA.org:oru-22941DiVA, id: diva2:527977
Available from: 2012-05-23 Created: 2012-05-23 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Atrial fibrillation: inflammatory and pharmacological studies
Open this publication in new window or tab >>Atrial fibrillation: inflammatory and pharmacological studies
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2012. p. 75
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 70
Keywords
Atrial fibrillation, inflammation, randomised, sudden cardiac
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-22590 (URN)978-91-7668-875-5 (ISBN)
Public defence
2012-06-15, Wilandersalen, Universitetssjukhuset, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2012-04-19 Created: 2012-04-19 Last updated: 2017-10-17Bibliographically approved

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Almroth, HenrikEnglund, Anders

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