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The biological response to three different nanostructures applied on smooth implant surfaces
Department of Prosthodontics, Faculty of Odontology, Malmö, University, Malmö, Sweden; Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Biomedical Laboratory Science and Technology, Faculty of Health and Society, Malmö University, Malmö, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Promimic AB, Göteborg, Sweden.
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2012 (English)In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 23, no 6, p. 706-712Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate the biological effects of three calcium phosphate (CaP) coatings with nanostructures on relatively smooth implant surfaces.

Material and methods: Stable CaP nanoparticle suspensions of different particle sizes and structures were coated onto implants by immersion and subsequent heat treatment. An uncoated implant was used as the control. After topographical and chemical characterizations, implants were randomly inserted into rabbit tibiae for removal torque (RTQ) testing. To confirm the biological reaction, implants were placed in the bilateral femurs of three rabbits.

Results: The topographical characterization showed that each surface had different nanostructural characteristics and X-ray photon spectroscopy showed various CaP compositions. The control and test groups had different nanotopographies; however, the differences among the test groups were only significant for Surfaces B and C and the rest were insignificant. The RTQ tests showed significantly higher values in two test groups (Surface A and Surface C). Histologically, no adverse effects were seen in any group. Histomorphometrical evaluation showed comparable or better osseointegration along the implant threads in the test groups.

Conclusion: The three different CaP coatings with nanostructures on the implant surfaces had enhancing effects on osseointegration. Along with the surface nanotopography, the CaP chemistry might have influenced the biological outcomes.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2012. Vol. 23, no 6, p. 706-712
Keywords [en]
Animal experiments, biomaterials, bone implant interactions, surface chemistry
National Category
Medical and Health Sciences Dentistry
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-23078DOI: 10.1111/j.1600-0501.2011.02182.xISI: 000303119000008PubMedID: 21488968Scopus ID: 2-s2.0-84860229593OAI: oai:DiVA.org:oru-23078DiVA, id: diva2:529713
Funder
Swedish Research CouncilKnowledge Foundation
Note

Funding Agencies:

Hjalmar Svensson Research Foundation

Örebro University 

Available from: 2012-05-31 Created: 2012-05-31 Last updated: 2018-09-11Bibliographically approved

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Johansson, Carina

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