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Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA)
Uppsala University, Uppsala, Sweden.
Uppsala University, Uppsala, Sweden.
Örebro University, School of Science and Technology.
Uppsala University, Uppsala, Sweden.
2012 (English)In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, ISSN 1532-0456, E-ISSN 1878-1659, Vol. 156, no 1, p. 29-36Article in journal (Refereed) Published
Abstract [en]

Perfluoroalkyl acids (PFAAs) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are developmental toxicants in various animal classes, including birds. Both compounds interact with peroxisome proliferator-activated receptors (PPARs), but it is not known whether activation of PPARs is involved in their embryo toxicity in birds. We exposed chicken embryos via egg injection at a late developmental stage to GW7647, a potent PPAR alpha agonist in mammals, and to PFOS or PFOA. Mortality was induced by PFOS and PFOA but not by GW7647. Transcripts of a number of genes activated by PPAR alpha agonists in mammals were analyzed in liver and kidney of 18-day-old embryos. Several of the genes were induced in both liver and kidney following exposure to GW7647. Treatment with PFOA resulted in induction of acylcoenzyme A oxidase mRNA in liver, whereas none of the genes were significantly induced by PFOS treatment. No up-regulation of gene transcription was found in kidney following treatment with PFOS or PFOA. Principal component analysis showed that PFOA caused an mRNA expression pattern in liver more similar to the pattern induced by GW7647 than PFOS did. Our findings do not support that the embryo mortality by PFOS and PFOA in chicken embryos involves PPAR alpha activation.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 156, no 1, p. 29-36
Keywords [en]
PPAR, PFOS, PFOA, Chicken, Embryo
National Category
Chemical Sciences
Research subject
Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-23696DOI: 10.1016/j.cbpc.2012.03.004ISI: 000304578400005Scopus ID: 2-s2.0-84860524094OAI: oai:DiVA.org:oru-23696DiVA, id: diva2:536810
Available from: 2012-06-25 Created: 2012-06-25 Last updated: 2017-12-07Bibliographically approved

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Kärrman, Anna

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