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Circulating levels of Persistent Organic Pollutants (POPs) among elderly men and women from Sweden: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology.ORCID iD: 0000-0002-4959-2807
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2012 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 44, p. 59-67Article in journal (Refereed) Published
Abstract [en]

Persistent Organic Pollutants (POPs) are a huge group of chemicals that have been linked to various adverse health effects in humans. Large epidemiological studies investigating gender differences in levels of POPs in the elderly are limited and the results from these are not always consistent. The present study was undertaken to examine the background levels of a broad range of POPs in human plasma samples among elderly men and women from Sweden and to assess the influence of gender. Levels of 23 POPs were determined in plasma samples collected during 2001-2004 from 1016 (50.2% women) 70year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). Measurements were performed using high resolution gas chromatography with high resolution mass spectrometry (HRGC-HRMS) and the POPs studied were 16 polychlorinated biphenyls (PCBs), five organochlorine (OC) pesticides, one dioxin, and one brominated flame retardant. The concentrations of the selected POPs were found similar, or comparable, to other studies of non-occupationally exposed populations from Sweden and Europe. Differences in levels of POPs between men and women were assessed by using Wilcoxon rank-sum (Mann-Whitney) test. Significant (p<0.0001) gender differences in levels of specific POPs were observed and a number of POP concentrations were found to differ between men and women. More specifically, levels of HCB, OCDD, and PCB congeners #74, #105, and #118 were found to be higher in women, while the rest of the majority of POPs were higher in men.

Place, publisher, year, edition, pages
2012. Vol. 44, p. 59-67
National Category
Natural Sciences Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-23923DOI: 10.1016/j.envint.2012.01.011ISI: 000304745900008OAI: oai:DiVA.org:oru-23923DiVA, id: diva2:539839
Available from: 2012-07-05 Created: 2012-07-05 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Development and application of high-throughput methods for analysis of persistent organic pollutants in human blood
Open this publication in new window or tab >>Development and application of high-throughput methods for analysis of persistent organic pollutants in human blood
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The general public is continuously exposed to a wide range of environmental pollutants. This thesis focuses on a group of anthropogenic chemicals referred to as persistent organic pollutants (POPs) that have been linked to various adverse health effects in humans.

The main objective of this thesis was focused on the development and application of high-throughput methods for analysis of a broad range of chlorinated, brominated, and fluorinated POPs in human blood.

After establishing that the methods were effective, the two methods were applied to human plasma samples to examine the background levels of a broad range of POPs in human plasma samples among elderly men and women from Sweden and to assess the influence of gender. Levels of a wide range of chlorinated, brominated, and fluorinated compounds were determined in plasma samples collected during 2001-2004 from 1, 016 (50.2% women) 70 year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). The POPs studied were 16 polychlorinated biphenyls (PCBs), 5 organochlorine pesticides (OCPs), 1 dioxin, 1 brominated flame retardant as well as 14 perfluoroalkyl substances (PFAS) including structural perfluorooctane sulfonic acid (PFOS) isomers. The majority of the studied compounds were detected in the 70-100% of the participants. The structural PFOS isomers were successfully quantified in a sub-sample of 25 men and women. Furthermore, gender differences in the concentrations of the POPs studied showed that the majority of chlorinated and brominated compounds were significantly different when comparing men and women in the study, while the concentrations of the fluorinated compounds were found to be less influenced by gender.

This thesis has, by using the developed high-throughput methods requiring only small amounts of human blood, provided background exposure information of a broad range of POPs for an epidemiological study.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2013. p. 70
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 12
Keywords
Human blood, POPs, Perfluoroalkylated substances, Structural isomers, Sample preparation, Column-switch, Mass spectrometry
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:oru:diva-28456 (URN)978-91-7668-936-3 (ISBN)
Public defence
2013-05-31, Hörsal B, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 10:00 (English)
Opponent
Supervisors
Available from: 2013-03-22 Created: 2013-03-22 Last updated: 2017-10-17Bibliographically approved

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Salihovic, SamiraLindström, Gunillavan Bavel, Bert

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