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Telomere length and regulatory proteins in human skeletal muscle with and without ongoing regenerative cycles
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Muscle & Exercise Physiology Research Group , RISPA)ORCID iD: 0000-0002-8071-4745
Département de Neurologie, Hôpitaux Universitaires, Strasbourg, France. (INSERM U692, Faculté de Médecine, Strasbourg, France)
School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Muscle and Exercise Physiology Research Group , RISPA)ORCID iD: 0000-0002-9831-0896
2012 (English)In: Experimental Physiology, ISSN 0958-0670, E-ISSN 1469-445X, Vol. 97, no 6, p. 774-784Article in journal (Refereed) Published
Abstract [en]

New insights suggest the existence of telomere regulatory mechanisms in several adult tissues. In this study, we aimed to assess in vivo telomere length and the presence of specific proteins involved in telomere regulation in a model of human skeletal muscle with (patients with dermatomyosis or polymyositis) and without ongoing regenerative events (healthy subjects). Mean (meanTRF) and minimal telomere (miniTRF) lengths and the expression of telomerase, tankyrase 1, TRF2 (telomeric repeat binding factor 2) and POT1 (protection of telomeres 1) were investigated in skeletal muscle samples from 12 patients (MYO) and 13 healthy subjects (CON). There was no significant shortening of telomeres in skeletal muscle from patients compared with control subjects (MYO, meanTRF length 11.0 ± 1.8 kbp and miniTRF length 4.7 ± 0.8 kbp; CON, meanTRF length 10.4 ± 1.1 kbp and miniTRF length 4.6 ± 0.5 kbp). Theoretically, telomere length can be controlled by endogenous mechanisms. Here, we show for the first time that expression levels of telomerase, tankyrase 1, TRF2 and POT1 were, respectively, six-, seven-, three- and fivefold higher in the nuclear fraction of skeletal muscle of MYO compared with CON (P < 0.05). This suggests the existence of endogenous mechanisms allowing for telomere regulation in skeletal muscle with ongoing cycles of degeneration and regeneration and a model where regulatory factors are possibly involved in the protection of skeletal muscle telomeres.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2012. Vol. 97, no 6, p. 774-784
National Category
Basic Medicine Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-24268DOI: 10.1113/expphysiol.2011.063818ISI: 000305460000010PubMedID: 22366562Scopus ID: 2-s2.0-84862604589OAI: oai:DiVA.org:oru-24268DiVA, id: diva2:543064
Note

Note: Institut national de la santé et de la recherche médicale (INSERM)

Available from: 2012-08-06 Created: 2012-08-06 Last updated: 2018-08-29Bibliographically approved

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Ponsot, ElodieKadi, Fawzi

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